Zeprodex (0.3/0.1%) 5ml Ear Drops

Dexamethasone, a potent synthetic corticosteroid, exerts its anti-inflammatory and immunosuppressive effects by binding to cytoplasmic glucocorticoid receptors, leading to the modulation of various genes involved in inflammation. It inhibits the production and release of pro-inflammatory mediators, such as cytokines and prostaglandins, thereby reducing inflammation and suppressing immune responses. On the other hand, Ciprofloxacin, a fluoroquinolone antibiotic, acts by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential enzymes for bacterial DNA replication and transcription. This inhibition results in the disruption of bacterial DNA synthesis, preventing bacterial replication and ultimately leading to bacterial cell death.

Dexamethasone, Ciprofloxacin

Corticosteroid, Antibiotic

drop

The following are the uses of Dexamethasone, Ciprofloxacin Drop:

• Used for treating severe eye infections like bacterial conjunctivitis
• Used to reduce inflammation and swelling after eye surgeries or injuries
• Used for managing eye allergies and allergic conjunctivitis
• Used to prevent and treat eye infections in patients with low immunity
• Used for treating corneal ulcers and infections
• Used to alleviate eye pain and redness caused by various conditions
• Used as an adjunct therapy for eye conditions requiring anti-inflammatory action
• Used to prevent and treat potential eye infections during contact lens wear

To be determined by the doctor

In the case of an overdose of Dexamethasone, symptoms may include increased heart rate, high blood pressure, and fluid retention. For Ciprofloxacin Drops, an overdose can lead to nausea, vomiting, and potential damage to the liver or kidneys. If an overdose is suspected, prompt medical attention is necessary. Treatment may involve managing symptoms and providing supportive care to prevent further complications. It is crucial to seek medical assistance immediately.

In the case of a missed dose of Dexamethasone, it is important to take the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Ciprofloxacin eye drops, if you miss a dose, apply the drops as soon as you remember. You can continue with the next dose at the regular scheduled time. It is generally safe to administer the missed dose if it is not too close to the next scheduled application.

To use Dexamethasone and Ciprofloxacin eye drops, wash your hands, tilt your head back, gently pull down the lower eyelid, and hold the dropper close to the eye, dispensing the prescribed number of drops into the eye, then close the eye gently to allow the medication to absorb.

Following are the conditions/situations when Dexamethasone and Ciprofloxacin eye drops should not be used:

• Do not use if you have a known allergy or hypersensitivity to Dexamethasone, Ciprofloxacin, or any other ingredients in the eye drops.
• Avoid using these eye drops if you have a fungal infection in or around your eyes.
• Not suitable for patients with viral eye infections, such as herpes simplex keratitis.
• Should not be used if you have a history of hypersensitivity or allergic reactions to similar medications.
• Contraindicated in individuals with a history of tendon disorders or tendon rupture related to fluoroquinolone antibiotic use.
• Not recommended for patients with corneal ulcers or perforations.
• Avoid using these eye drops if you have untreated bacterial or fungal eye infections.
• Do not use if you have a history of myasthenia gravis, as it can worsen muscle weakness.

The side effects of Dexamethasone may include:

• Increased appetite and weight gain
• Indigestion or stomach discomfort
• Mood changes, including feeling anxious or restless
• Sleep disturbances
• Headache
• Dizziness or spinning sensation
• Skin thinning or bruising
• Eye discomfort or itching
• Mild eye redness or irritation
• Watery eyes
• Blurred vision or other visual disturbances
• Dry eyes
• Headache
• Allergic reactions, such as a rash or itching

Following are the precautions and warnings for Dexamethasone, Ciprofloxacin Eye Drops:

• Do not use if you are allergic to any of the ingredients or similar antibiotics. Inform your doctor of any previous allergic reactions.
• This medication is for external use only. Do not swallow or inject.
• Avoid contact with eyes. If contact occurs, immediately rinse with plenty of water.
• Prolonged use may lead to increased eye pressure and potential optic nerve damage. Regular eye pressure checks are recommended.
• Inform your doctor if you have a history of eye infections, injuries, or surgeries before using these drops.
• These eye drops may cause temporary blurred vision. Avoid driving or operating machinery until your vision is clear.
• Store the eye drops at room temperature and away from direct sunlight. Keep out of reach of children.

Following are the drug interactions for Dexamethasone and Ciprofloxacin Drops:

• Dexamethasone can increase the risk of tendon rupture when used with fluoroquinolones like Ciprofloxacin, especially in elderly patients.
• Dexamethasone may reduce the effectiveness of live vaccines, so avoid live vaccines during and shortly after treatment.
• The use of Dexamethasone with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and ulcers.
• Anticoagulants like warfarin can have their effects altered by Dexamethasone, requiring close monitoring of coagulation parameters.
• Ciprofloxacin can enhance the effects of caffeine, leading to increased caffeine-related side effects.
• Ciprofloxacin may decrease the elimination of Theophylline, elevating its blood levels and potentially causing side effects.
• The efficacy of Ciprofloxacin may be reduced when taken with antacids containing calcium, magnesium, or aluminum.
• Probenecid can increase the blood levels of Ciprofloxacin, potentially increasing the risk of side effects.

Following are the food interactions for Dexamethasone and Ciprofloxacin Drops:

• Avoid consuming excessive amounts of salty or highly processed foods while using Dexamethasone, as it can lead to fluid retention and elevated blood pressure.
• Grapefruit juice should be avoided with Ciprofloxacin Drops as it can increase the drug's concentration in the blood, potentially leading to increased side effects.
• Limit caffeine intake from coffee, tea, or energy drinks as Dexamethasone may increase anxiety and nervousness.
• Avoid alcohol consumption with Ciprofloxacin Drops as it can lead to increased side effects such as dizziness, drowsiness, and gastrointestinal issues.
• Avoid high-sugar foods and beverages, as Dexamethasone can cause elevated blood sugar levels.
• Dairy products may interfere with the absorption of Ciprofloxacin Drops, so consider spacing out dairy intake and medication by a few hours.
• Maintain a balanced diet rich in fruits, vegetables, whole grains, and lean proteins to support overall health during treatment.
• Stay hydrated by drinking plenty of water, especially when using Ciprofloxacin Drops, to reduce the risk of kidney complications.

Dexamethasone and Ciprofloxacin eye drops should be stored at room temperature, ideally between 68°F and 77°F (20°C and 25°C), in a cool and dry place. Protect the drops from direct sunlight and heat as high temperatures can affect the medication's potency. Keep the bottle tightly closed when not in use to prevent contamination. Always check the expiration date, and do not use the drops if they have expired. For disposal, do not pour the medication down the sink or toilet; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for advice on safe disposal methods. Keep the eye drops out of the reach of children and pets to prevent accidental ingestion.

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Following are the quick tips for this Drops:

• Administer the medication as prescribed, ensuring accuracy in dosage and timing.
• If using eye drops, gently pull down the lower eyelid and instill the drops without touching the bottle to the eye.
• For ear drops, warm the bottle in your hands, then fill the ear canal and allow the excess to drain out.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Do not abruptly stop taking this medication; follow your doctor's instructions for tapering.
• Inform your doctor if you have any allergies or medical conditions before starting this medication.
• Store the medication at room temperature, away from light and moisture.
• Wash your hands before and after using the eye or ear drops to maintain hygiene.
• For eye drops, tilt your head back, pull the lower eyelid down, and instill the drops into the pocket without touching the eye.
• When using ear drops, lie down or tilt your head to the side, fill the ear canal, and let the excess drain out.
• Avoid contamination by not touching the dropper tip to your eye, ear, or any surface.
• Do not share your medication with others, even if they have similar symptoms.
• Store the eye or ear drops at room temperature, away from heat and direct sunlight.
• If you wear contact lenses, remove them before applying eye drops and wait at least 15 minutes before reinserting them.