Zestril (20mg) 14 Tablets

Lisinopril, a commonly prescribed angiotensin-converting enzyme (ACE) inhibitor, exerts its mechanism of action by selectively inhibiting the ACE enzyme in the body. ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure. By blocking this conversion, lisinopril prevents the formation of angiotensin II, leading to reduced vasoconstriction and decreased blood pressure. It also promotes the relaxation of blood vessels by enhancing the levels of bradykinin, a vasodilatory peptide. This dual action results in improved blood flow, reduced vascular resistance, and ultimately, a decrease in blood pressure. Lisinopril's mechanism primarily focuses on the renin-angiotensin-aldosterone system, making it effective in managing hypertension and heart failure by regulating blood vessel tone and fluid balance.

Lisinopril 20mg

Angiotensin-converting enzyme (ACE) inhibitor.

Tablet

The following are the uses of Lisinopril 20mg Tablet:

• Used for treating high blood pressure, helping to lower and control blood pressure levels.
• Used for improving heart function in patients with heart failure, reducing strain on the heart.
• Used for protecting the kidneys in people with diabetes and high blood pressure, slowing the progression of kidney disease.
• Used for preventing, treating, and managing heart attacks and their aftermath, including reducing complications.
• Used for improving survival rates and heart function after a heart attack, as part of a comprehensive treatment plan.
• Used for managing certain chronic conditions, such as heart disease and diabetes, to reduce associated risks.
• Used for helping to prevent further cardiovascular events, such as strokes or heart attacks, in high-risk patients.

Follow these dosage instructions:

• Adult Dosage

5 milligrams (mg) orally per day. Your doctor will determine the length of the treatment and may adjust the dose after some time. The dose should not exceed more than 40mg per day.

• Child Dosage

The dosage for the child is strictly recommended by the doctor.

In the case of an overdose of Lisinopril 20mg Tablets, it is crucial to recognize the symptoms, which may include a severe drop in blood pressure, dizziness, and fainting. Immediate medical attention is necessary, and emergency services should be contacted promptly. Treatment for overdose may involve monitoring vital signs, administering intravenous fluids, and supporting respiratory function. Prompt action can significantly impact the outcome and reduce the risk of severe complications.

In the case of a missed dose of Lisinopril 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions for catching up on missed doses safely.

To take Lisinopril 20mg Tablets, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional, without crushing, chewing, or breaking the tablet.

Following are the conditions/situations when Lisinopril 20mg Tablet should not be used:

• Should not be used in patients with a known allergy to Lisinopril or any angiotensin-converting enzyme (ACE) inhibitors.
• Contraindicated in individuals with a history of angioedema after previous treatment with ACE inhibitors.
• Not recommended for patients with severe renal impairment or kidney disease.
• Should not be used in individuals with bilateral renal artery stenosis.
• Contraindicated during pregnancy, especially during the second and third trimesters.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should not be used in patients with a condition called aortic stenosis (narrowing of the aortic valve in the heart).
• Contraindicated in patients with low blood pressure (hypotension).
• Not recommended for individuals undergoing major surgery or receiving anesthesia.

The side effects of Lisinopril 20mg Tablet may include:

• Dizziness
• Fatigue
• Headache
• Cough
• Diarrhea
• Skin rash
• Increased sensitivity to sunlight

Following are the precautions and warnings for Lisinopril 20mg Tablet:

• Do not start or continue this medication if you are pregnant, planning to become pregnant, or breastfeeding without consulting your doctor, as it may cause harm to the fetus or infant.
• Lisinopril can cause a severe allergic reaction (angioedema) in some individuals; seek immediate medical attention if you experience swelling of the face, lips, throat, or tongue.
• This medication may cause dizziness and lightheadedness, especially during the first few days of use or after a dose increase. Avoid driving or operating heavy machinery until you know how it affects you.
• Regular monitoring of kidney function and blood pressure is necessary while taking Lisinopril, particularly in patients with existing kidney disease.
• Diabetic patients should monitor their blood sugar levels regularly, as Lisinopril may cause an increase in blood sugar.
• Inform your doctor about all the medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.
• If you have a history of liver problems, discuss the use of Lisinopril with your doctor, as it may not be suitable for you.
• Discontinue Lisinopril and seek medical attention if you develop a persistent, non-productive cough, as it could be a side effect of the medication.

Following are the drug interactions for Lisinopril 20mg Tablet:

• Lisinopril can increase the blood levels of lithium, leading to lithium toxicity. Close monitoring of lithium levels is necessary.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Lisinopril and can increase the risk of kidney problems.
• When combined with diuretics, Lisinopril may cause excessive potassium loss, leading to hypokalemia.
• The use of Lisinopril with other angiotensin-converting enzyme (ACE) inhibitors can increase the risk of severe hypotension and kidney dysfunction.
• Lisinopril may enhance the blood sugar-lowering effect of oral diabetes medications, increasing the risk of hypoglycemia.
• Taking Lisinopril with potassium-sparing diuretics may lead to hyperkalemia, a condition with elevated potassium levels.
• Caution is advised when using Lisinopril with other medications that affect the immune system, as it may increase the risk of infections.

Following are the food interactions for Lisinopril 20mg Tablet:

• Consuming high-sodium foods can reduce the effectiveness of Lisinopril, as it may counteract the medication's blood pressure-lowering effects.
• Alcohol may increase the risk of dizziness and lightheadedness, especially when starting Lisinopril treatment. It is advisable to limit alcohol consumption.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Lisinopril, potentially leading to increased drug levels in the body and an elevated risk of side effects.
• Maintaining a balanced diet with limited saturated fats and cholesterol is recommended, as Lisinopril may not effectively control blood pressure if the diet is high in these substances.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation to prevent excessive potassium levels in the blood.
• Salt substitutes containing potassium should be used cautiously as Lisinopril can increase potassium levels, and excessive potassium can be harmful.
• There are no specific food restrictions, but it is advisable to maintain a consistent dietary pattern for optimal medication effectiveness.
• Always consult your healthcare provider for personalized dietary advice while taking Lisinopril.

Lisinopril 20mg tablets should be stored in a dry and cool environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures by storing them away from heat sources like radiators or ovens. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not dispose of the tablets by flushing or pouring them into water sources; instead, consult a pharmacist or healthcare professional for safe disposal methods. Keep the medication securely stored, away from children, to prevent accidental ingestion.

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Following are the quick tips for Lisinopril 20mg Tablet:

• Start with a low dose and gradually increase as advised by your doctor.
• Swallow the tablet whole with a sufficient amount of water.
• Maintain a consistent daily dose timing for better blood pressure control.
• Avoid sudden discontinuation; consult your doctor for dose adjustments.
• Regular blood pressure monitoring is essential during treatment.
• Inform your doctor about all medications you're taking to prevent interactions.
• Store the tablets in a cool, dry place, away from direct sunlight.