Zevoxid 100mg/5ml 60ml syrup

Linezolid, the active ingredient in the 100mg syrup/suspension, primarily acts by inhibiting bacterial protein synthesis. It specifically targets the 50S subunit of the bacterial ribosome, binding to a site on the 23S ribosomal RNA. This binding prevents the formation of a functional complex between the 50S subunit and the 30S subunit, which is essential for the initiation of protein synthesis. By disrupting this process, Linezolid effectively stops the growth and multiplication of bacteria, leading to their death. This mechanism of action is unique and makes Linezolid effective against a range of Gram-positive bacteria, including those resistant to other antibiotics.

Linezolid 100mg

Oxazolidinone antibiotic

Suspension

The following are the uses of Linezolid 100mg Syrup/Suspension:

• Used for treating severe bacterial infections like pneumonia and skin structure infections in children.
• Used for its effectiveness against multidrug-resistant bacteria.
• Used for its unique mechanism of action, inhibiting bacterial protein synthesis.
• Used for its ability to penetrate tissues and achieve therapeutic levels in hard-to-reach sites.
• Used for managing infections in patients with allergies or resistance to other antibiotics.
• Used for its oral formulation, making it convenient for children who cannot swallow tablets.
• Used for its relatively well-tolerated side effect profile compared to other antibiotics.
• Used under medical supervision, ensuring appropriate dosing and monitoring for potential adverse effects.

In the case of an overdose of Linezolid 100mg Syrup/Suspension, prompt medical attention is required. Symptoms may include severe nausea, vomiting, diarrhea, dizziness, and changes in blood pressure or heart rate. The severity of these symptoms can vary based on the amount ingested and individual factors. Treatment involves managing these symptoms and providing supportive care to ensure the patient's stability and recovery. It is crucial to seek medical assistance immediately if an overdose is suspected.

In the case of a missed dose of Linezolid 100mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure the medication's effectiveness.

To administer Linezolid 100mg Syrup/Suspension, shake the bottle well, use a measuring device like a syringe to extract the prescribed dose, and administer it orally, following the dosing instructions provided by your healthcare professional, typically twice a day with or without food.

Following are the conditions/situations when Linezolid 100mg Syrup/Suspension should not be used:

• Avoid using Linezolid if you have a known allergy or hypersensitivity to Linezolid or any other ingredients in the medication.
• Do not administer to patients with a history of seizures or conditions that increase the risk of seizures, as Linezolid may lower the seizure threshold.
• Contraindicated in patients with a rare blood disorder called granulocytopenia or severe liver impairment.
• Should not be used in individuals with certain blood disorders, such as anemia or low white blood cell count.
• Not suitable for children under 18 years of age, as the safety and efficacy in this population have not been established.
• Avoid using Linezolid if you have uncontrolled high blood pressure.
• Do not use if you have a history of peripheral neuropathy or nerve damage.
• Linezolid is not recommended for individuals with a history of severe kidney disease or kidney failure.

The side effects of Linezolid 100mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dry mouth
• Loss of appetite
• Constipation
• Changes in taste, including metallic taste

Following are the precautions and warnings for Linezolid 100mg Syrup/Suspension:

• This medication should be used with caution in patients with a history of seizures or conditions affecting the central nervous system, as it may increase the risk of seizures.
• Linezolid may cause changes in blood pressure, so regular monitoring is necessary, especially in patients with hypertension or hypotension.
• Patients with diabetes should be aware that Linezolid can cause hyperglycemia or hypoglycemia, and blood sugar levels should be monitored closely.
• It can lead to a decrease in white blood cell count, so regular blood tests are recommended to monitor this effect.
• Patients with liver disease should exercise caution as Linezolid is metabolized by the liver, and dosage adjustments may be required.
• Avoid using Linezolid if you have a known allergy to any of its ingredients, as it may cause severe allergic reactions.
• This medication may cause dizziness and blurred vision; patients should not drive or operate heavy machinery until they know how the medication affects them.

Following are the drug interactions for Linezolid 100mg Syrup/Suspension:

• Linezolid can interact with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome.
• It may lower blood pressure when taken with antihypertensive medications.
• Linezolid can decrease the effectiveness of thyroid medications like levothyroxine.
• The risk of bleeding may increase when combined with anticoagulants or antiplatelet drugs.
• Drugs metabolized by the liver, such as certain antidepressants and antipsychotics, may have increased blood levels when used with Linezolid.
• Linezolid can reduce the effectiveness of hormonal contraceptives, requiring alternative birth control methods.
• It may interact with medications affecting the central nervous system, potentially leading to increased sedation.

Following are the food interactions for Linezolid 100mg Syrup/Suspension:

• Avoid consuming tyramine-rich foods like aged cheeses, cured meats, fermented foods, and certain fruits (avocados, overripe bananas) as Linezolid can inhibit the breakdown of tyramine, leading to a potentially dangerous increase in blood pressure.
• Consuming foods high in Vitamin K, such as leafy greens, broccoli, and soybeans, may reduce the effectiveness of Linezolid, as it interferes with the production of blood-clotting factors.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of Linezolid, leading to increased drug levels and potential side effects.
• Limit the consumption of high-fat meals as they can slow down the absorption of Linezolid, delaying its therapeutic effect.
• Alcohol intake should be minimized or avoided as it can increase the risk of side effects, especially gastrointestinal issues and dizziness.
• Avoid excessive consumption of caffeinated beverages as they can interact with Linezolid, potentially causing increased heart rate and blood pressure.
• Linezolid may cause a decrease in appetite, so ensure a balanced diet to maintain adequate nutrition.
• Always follow your healthcare provider's advice regarding dietary restrictions and interactions during Linezolid therapy.

Linezolid 100mg Syrup/Suspension should be stored in a secure and controlled environment, preferably in a designated medicine cabinet or storage area. Keep the medication at room temperature, maintaining a consistent temperature between 68°F and 77°F (20°C and 25°C). Avoid exposing the syrup to extreme temperatures, including direct sunlight, excessive heat, or freezing conditions, as this can alter its effectiveness. Ensure the bottle is tightly sealed after each use to prevent contamination and maintain its integrity. It is crucial to discard any unused or expired Linezolid syrup responsibly; do not pour it down the drain or flush it. Instead, contact your local pharmacy or healthcare provider for guidance on safe disposal methods in your area. Keep the medication out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing this medication.

Following are the quick tips for Linezolid 100mg Syrup/Suspension:

• Always follow your doctor's instructions for the prescribed dosage and duration of this medication.
• Ensure you measure the correct dose using a calibrated measuring device.
• Administer the syrup with a glass of water to enhance absorption.
• Maintain a consistent daily routine for taking the medication to maximize its effectiveness.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication.
• Regularly monitor your health and report any persistent or worsening symptoms to your healthcare provider.