Zexa (10mg) 56 Tablets

Memantine exerts its effects on glutamatergic synaptic activity, which is implicated in the pathogenesis of Alzheimer's disease. It is thought to modulate this activity, via uncompetitive NMDA receptor blockade, which is considered very safe, interfering with the glutamatergic action only during periods of excess neurotransmitter concentration. Memantine's mechanism of action differs from other AD medications, as it facilitates the activation of metabolic enzymes involved in the synthesis of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF). These enzymes are also linked to the synthesis of important neurotransmitters, including dopamine, serotonin, and norepinephrine, which are involved in mood and cognition. Another proposed mechanism of action is the protection of the dopaminergic system in the brain against the toxicity of amyloid beta proteins, which are a major feature of Alzheimer's disease pathology. Memantine has been shown to prevent the loss of dopaminergic neurons in animal models of Parkinson's disease, which is another neurodegenerative disorder associated with these protein aggregates. Overall, memantine's mechanism of action involves the protection of dopaminergic neurons via inhibition of excess glutamatergic activity, as well as promoting the release of neurotrophic factors and neurotransmitters.

NMDA Receptor Antagonist

Unveiling its multifaceted uses and transformative applications as follows:

• Memantine HCl 10mg is prescribed as part of a overall treatment program for schizophrenia.
• Dementia and cognitive impairment stemming from Alzheimer's disease can be treated with Memantine HCl 10mg.
• Memantine HCl 10mg has also proven to be effective in reducing the severity of vascular dementia associated with Parkinson's disease.
• Memantine HCl 10mg is used to treat moderate to severe dementia caused by Alzheimer's disease.
• Is sometimes prescribed for the treatment of HIV-associated dementia.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Memantine is a medication utilised to treat moderate-to-severe Alzheimer's disease, commonly prescribed at an initial dose of 5-10 mg and can be increased to 20mg daily, under a doctor's supervision.
• Memantine dosage is weight-based for children with Alzheimer's disease, as determined by a doctor.
• It's vital to adhere to your doctor's dosage instructions and monitor for any side effects.

An overdose of Memantine HCl may lead to mild symptoms such as nausea, vomiting, dizziness, and headaches, which should fade away within a few hours. Despite the mild nature of these side effects, it is highly recommended to seek medical attention if you suspect an overdose has occurred. The treatment consists of providing supportive care, which involves monitoring vital signs and managing any symptoms that arise. In more severe cases, gastric lavage or pumping may be performed to remove excess medication from the stomach. Active charcoal may also be administered to prevent further absorption of Memantine HCl. It is important to follow instructions from your physician when taking medications and to not share them with others. Seek medical attention immediately if you suspect you've experienced an overdose on Memantine HCl.

It is crucial to follow the prescribed dosage schedule for Memantine HCl 10mg. If you miss a dose, you may take it as soon as you remember, but if it is almost time for the next scheduled dose, it's best to skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one as it can lead to an overdose. It is essential to seek advice from a qualified medical professional like your doctor or pharmacist if you have any questions or concerns about missing a dose to ensure you respond adequately to the treatment and minimize any potential risks.

Memantine is a film-coated tablet taken orally to treat moderate to severe Alzheimer's disease. It is typically prescribed at a dosage between 5 mg and 20 mg per day, and in this scenario, you would take 10 mg once daily. It is important to follow the medication guide provided by your pharmacist and swallow the tablet whole, preferably at the same time each day. Avoid taking grapefruit or its products as it may interfere with the levels of the drug in your body. If you miss a dose, skip it and take the next dose at the regular time, and it would be best if you never doubled the dose to make up for a missed one. It is critical to consult a healthcare professional for any questions or concerns you may have.

Discerning instances where this medication may not be appropriate:

• Memantine HCl 10mg is a medication that is typically used to treat moderate to severe Alzheimer's disease.
• It should be prescribed and administered by a medical professional and taken under supervision.
• It is not recommended for people who are allergic to memantine or any of the other ingredients in the medication.
• People with glaucoma or a recent history of suicidal thoughts or behavior should also not take this medication.

Unraveling the side effects lurking behind this medications are as follows:

• Dizziness
• Confusion
• Headache
• Insomnia
• Anxiety
• Agitation
• Disorientation
• Hypotension (low blood pressure)
• Fatigue
• Indigestion
• Diarrhea
• Nausea
• Vomiting
• Irritability
• Loss of appetite
• Weight loss
• Urinary frequency
• Impaired cognition

When using this medication, patients should be aware of the following warnings and precautions:

• Individuals with epilepsy, a history of seizure disorders, or predisposing factors for epilepsy should use this medication with caution due to the potential risk of seizures.
• Patients with cardiovascular disease, such as uncontrolled hypertension, recent myocardial infarction, or uncompensated congestive heart failure, should consult their healthcare provider before use.
• Conditions that may increase urinary pH, including drastic dietary changes (e.g., switching from a high-protein to a vegetarian diet), renal tubular acidosis, severe urinary tract infections, and the use of alkalinizing agents (e.g., sodium bicarbonate, carbonic anhydrase inhibitors), may require special consideration.
• Concomitant use with other NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan) should be avoided due to potential interactions.
• Caution is advised in patients with renal impairment and severe hepatic impairment.
• The safety of this medication during pregnancy and lactation has not been established; consult a healthcare provider to evaluate risks and benefits.

Drug interactions with memantine include:

• Other NMDA antagonists (e.g., ketamine) (may increase the risk of adverse effects- monitor for changes in neurological status)
• Acetylcholinesterase inhibitors (e.g., donepezil) (may enhance effects and side effect- monitor for increased cholinergic activity)
• Anticholinergics (e.g., atropine) (may counteract memantine's effects- monitor for changes in efficacy)
• Cimetidine (may increase memantine levels- monitor for potential side effects)
• Urinary alkalinizers (e.g., sodium bicarbonate) (may increase memantine levels- monitor for increased side effects)
• Renal impairment (may require dose adjustments- monitor renal function and adjust dosage as needed)
• Alcohol (may enhance CNS depressant effects- monitor for increased drowsiness or dizziness)

In order to ensure the safety and effectiveness of the drug, specific storage instructions must be followed carefully. Memantine HCl 10mg should be stored at room temperature, within the range of 68°F and 77°F (20°C and 25°C). The medication should be kept in its original container, tightly sealed, and away from heat, direct sunlight, and moisture. Specifically, avoiding storage in the bathroom or near a sink is recommended due to the high humidity levels in those environments which could affect the drug's integrity. It is also important to keep the medication out of reach of children and pets due to potential harm to them. Consumption of an expired drug can be harmful to one's health, and thus, the medication should be discarded if expired. To ensure the safekeeping of Memantine HCl 10mg, always prioritize checking the label for any specific storage instructions provided by the pharmacist or manufacturer. Following these storage instructions will ensure that Memantine HCl 10mg remains effective and safe for its intended use in managing Alzheimer's disease.