ZEXTRA 200MG TAB

Gatifloxacin, a 200mg tablet, exerts its antimicrobial effect through the inhibition of DNA gyrase and topoisomerase IV, crucial enzymes responsible for bacterial DNA replication and repair. This mechanism disrupts the bacteria's ability to replicate and repair their genetic material, leading to cell death. Specifically, gatifloxacin binds to these enzymes, preventing them from unwinding and supercoiling DNA, which is essential for DNA replication and cell division in susceptible bacteria. This targeted action contributes to the drug's effectiveness in treating various bacterial infections.

Gatifloxacin 200mg

Fluoroquinolone antibiotic.

Tablet

The following are the uses of Gatifloxacin 200mg Tablet:

• Used for treating bacterial infections, particularly those affecting the lungs and airways.
• Used for managing chronic bronchitis and pneumonia.
• Used for eye infections like conjunctivitis and corneal ulcers.
• Effective for skin infections, including cellulitis and abscesses.
• Used in post-surgery infections to prevent complications.
• Can treat urinary tract infections and prostate infections.
• Provides relief from bacterial gastroenteritis and traveler's diarrhea.
• Used for community-acquired respiratory infections.

In the case of an overdose of Gatifloxacin 200mg Tablets, several symptoms may occur, including nausea, vomiting, dizziness, and headaches. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly if an overdose is suspected. Treatment for overdose may involve supportive care and monitoring of vital signs, as well as managing any specific symptoms that arise. Prompt medical intervention can help mitigate potential complications.

In the case of a missed dose of Gatifloxacin 200mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication without compromising its effectiveness. It is advisable to maintain a consistent dosing routine to ensure the best therapeutic outcome.

To take Gatifloxacin 200mg Tablet, swallow the tablet whole with a full glass of water, ensuring you do not break, crush, or chew the tablet, and follow the dosage instructions provided by your healthcare professional, typically taken once or twice a day as directed.

Here are the circumstances under which Gatifloxacin 200mg Tablet should not be administered:

• Avoid in individuals with a known hypersensitivity or allergy to Gatifloxacin or other quinolone antibiotics.
• Not suitable for patients with a history of tendon disorders or tendon rupture, especially after previous quinolone therapy.
• Contraindicated in patients with myasthenia gravis as it can worsen muscle weakness.
• Should not be used in individuals with a prolonged QT interval or a history of cardiac arrhythmias.
• Not recommended for children and adolescents below 18 years of age due to potential risks of joint and tendon disorders.
• Avoid in patients with a history of epilepsy or seizures, as it may lower the seizure threshold.

The side effects of Gatifloxacin 200mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Changes in blood sugar levels

Following are the precautions and warnings for Gatifloxacin 200mg Tablet:

• Gatifloxacin should not be used in patients with a known hypersensitivity or allergy to this medication or other quinolone antibiotics.
• This medication can cause serious tendon disorders, including tendon rupture, which can occur within hours or days of taking the drug. Patients should be advised to discontinue the drug at the first sign of tendon pain or inflammation.
• It may cause central nervous system (CNS) side effects like dizziness, headache, and lightheadedness. Patients should avoid driving or operating heavy machinery if they experience these symptoms.
• Gatifloxacin can increase the sensitivity of the skin to sunlight, leading to severe sunburn. Patients should minimize sun exposure and use protective measures when outdoors.
• Elderly patients are more prone to certain side effects, including tendon problems and CNS effects. Close monitoring is necessary for this age group.
• Patients with a history of epilepsy or other seizure disorders should use this medication with caution, as it may lower the seizure threshold.
• Gatifloxacin can cause changes in blood sugar levels, so diabetic patients should monitor their blood sugar closely during treatment.
• It should be used with caution in patients with kidney or liver disease, as dosage adjustments may be required.

Following are the drug interactions for Gatifloxacin 200mg Tablet:

• Avoid combining with other drugs that prolong the QT interval (e.g., certain antiarrhythmics, antipsychotics, or antihistamines) as this may increase the risk of arrhythmias.
• Gatifloxacin may reduce the effectiveness of live vaccines (e.g., measles, mumps, rubella) due to its antibacterial effect.
• Theophylline levels may increase when used with Gatifloxacin, potentially leading to theophylline toxicity.
• Antacids containing aluminum, magnesium, or calcium can reduce the absorption of Gatifloxacin, so they should be taken at least 2 hours apart.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of central nervous system stimulation and seizures when taken with Gatifloxacin.
• The risk of tendinitis and tendon rupture may be increased when used with corticosteroids.
• Gatifloxacin may enhance the effects of oral anticoagulants, requiring close monitoring of coagulation parameters.

Following are the food interactions for Gatifloxacin 200mg Tablet:

• Avoid consuming dairy products (like milk, cheese, yogurt) within 2 hours before or after taking Gatifloxacin as calcium can bind with the medication and reduce its absorption.
• Iron-rich foods like red meat, liver, and spinach can decrease the absorption of Gatifloxacin, so it's best to separate their consumption by at least 2 hours.
• Multivitamins and mineral supplements containing zinc, magnesium, or iron should be taken at different times than Gatifloxacin to prevent reduced absorption.
• Consuming caffeine with Gatifloxacin may increase the risk of central nervous system side effects like nervousness, anxiety, and insomnia.
• Avoid high-fat meals as they can slow down the absorption of Gatifloxacin and potentially reduce its effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Gatifloxacin in the blood, leading to an increased risk of side effects.
• Alcohol should be limited or avoided as it can increase the risk of central nervous system side effects and may also decrease the effectiveness of the medication.

Gatifloxacin 200mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature, ensuring it stays between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture. It's crucial to place the medication out of children's reach to prevent accidental consumption. When disposing of unused or expired tablets, avoid flushing them or throwing them into the trash. Instead, consult your pharmacist or local waste disposal company for guidance on safe disposal methods to minimize environmental impact. Proper storage and disposal practices are essential to ensure the effectiveness of the medication and protect the well-being of your household.

Following are the quick tips for Gatifloxacin 200mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Take it at the same time each day to maintain consistent levels.
• Avoid taking with dairy products; take 2 hours before or after consuming dairy.
• Complete the full course even if you feel better; do not stop early.
• Store in a cool, dry place, away from sunlight and moisture.
• Inform your doctor about all medications you are taking.