Zohydro (1/1%) 10g Cream

Clotrimazole is an antifungal medication that functions through a multi-step mechanism of action. First, it penetrates fungal cell membranes. It then inhibits the synthesis of ergosterol, a crucial component of the fungal cell membrane. This disruption compromises the integrity of the membrane, leading to increased permeability and leakage of cellular contents. Ultimately, this inhibits fungal growth and replication. Clotrimazole is particularly effective against a wide range of fungal infections, including Candida species and dermatophytes.

Antifungal

Clotrimazole dosage for the indication of fungal skin infections, with a duration of 2-4 weeks or as advised:

• Adults and Children - Apply a thin layer to the affected area twice daily for 2-4 weeks.

Overdose may lead to gastrointestinal distress. Seek medical help if symptoms persist.

If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

Applied topically to the affected area, usually once or twice daily. Follow the directions for application.

Clotrimazole should not be used if:

• Hypersensitivity
• Viral infections
• Pregnancy (during first trimester, topical use)

The drug interactions with clotrimazole include:

• CYP3A4 Substrates (e.g., statins) – Can increase the levels of these drugs.
• Warfarin – Can enhance the effects of warfarin, increasing the risk of bleeding.

Clotrimazol has no documented food interactions that affect their efficacy or safety.

Clotrimazole should be stored at room temperature, away from light and moisture. It should be kept in its original packaging and out of reach of children. Dispose of any expired or unused Clotrimazole according to local disposal guidelines or use a drug take-back program.