ZOLADEX DEPOT 3.6MG INJ

Goserelin 3.6mg injection works by mimicking the action of the body's natural gonadotropin-releasing hormone (GnRH). When administered, goserelin initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continued use, it desensitizes the pituitary gland, leading to a reduction in the production of LH and FSH. This decrease in gonadotropin secretion results in suppressed production of sex hormones, including testosterone and estrogen, in the gonads. This mechanism is particularly useful in the treatment of hormone-sensitive conditions, as it helps to reduce the levels of circulating sex hormones, thereby inhibiting the growth and spread of hormone-dependent tumors.

goserelin 3.6mg

GnRH agonist

injection

The following are the uses of goserelin 3.6mg injection:

• Used for treating advanced prostate cancer by reducing testosterone production.
• Used to shrink fibroids in women before surgery, easing symptoms like heavy bleeding.
• Used in treating breast cancer in women who have not yet reached menopause.
• Used to manage endometriosis, reducing pain and inflammation.
• Used for fertility treatments, controlling ovulation timing.
• Used to lower testosterone levels in transgender women as part of gender-affirming hormone therapy.
• Used in certain cases of early puberty to halt premature sexual development.

In the case of an overdose of Goserelin 3.6mg injection, it is important to seek medical advice promptly. Overdose symptoms may include severe hot flashes, night sweats, and bone pain. Medical professionals should be informed about the amount ingested and the time of the overdose. Treatment may involve supportive care and managing symptoms until the effects of the medication wear off. It is crucial to follow the prescribed dosage to prevent such incidents.

In the case of a missed dose of Goserelin 3.6mg injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your treatment plan. It is advisable to set reminders or alarms to help you remember to take your medication at the correct time each day.

To administer the Goserelin 3.6mg injection, clean the injection site with an alcohol swab, insert the needle subcutaneously or intramuscularly as directed by your healthcare provider, inject the medication slowly, and then safely dispose of the used needle and syringe in a sharps container.

Here are the situations when Goserelin 3.6mg Injection should not be used:

• Should not be administered to individuals with a known hypersensitivity or allergy to Goserelin or any similar medications.
• Contraindicated in patients with a history of severe kidney or liver disease.
• Not suitable for individuals with uncontrolled diabetes.
• Should not be used during pregnancy or breastfeeding.
• Contraindicated in patients with osteoporosis, as it may worsen bone density.
• Not recommended for individuals with a history of blood clots or stroke.
• Should not be used in patients with undiagnosed vaginal bleeding.
• Not suitable for those with uncontrolled hypertension.
• Contraindicated in women with a history of endometrial cancer.
• Should be used with caution in patients with a history of depression or other psychiatric disorders.

The side effects of Goserelin 3.6mg Injection may include:

• Hot flashes
• Night sweats
• Weight gain
• Fatigue and weakness
• Mood changes, including depression or irritability
• Headaches
• Difficulty concentrating
• Bone pain or joint discomfort

Following are the precautions and warnings for Goserelin 3.6mg Injection:

• Patients with a known hypersensitivity or allergy to goserelin or any of the excipients in the injection should not use it.
• This medication is not recommended for individuals with uncontrolled diabetes or undiagnosed vaginal bleeding.
• Caution is advised in patients with osteoporosis, as goserelin may reduce bone density. Regular monitoring is necessary.
• Goserelin can cause dizziness; patients should avoid driving or operating heavy machinery if affected.
• It may lead to a temporary increase in bone pain and urinary frequency, especially during the first few weeks of treatment.
• Patients with a history of kidney or liver disease should be monitored closely, as goserelin can affect these organs.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Patients should be regularly assessed for signs of heart disease, as goserelin may increase the risk of cardiovascular events.

Following are the drug interactions for Goserelin 3.6mg Injection:

• Concomitant use with other gonadotropin-releasing hormone (GnRH) agonists may lead to additive effects and increased risk of side effects.
• The effectiveness of goserelin may be reduced when used with enzyme inducers like rifampin, potentially leading to treatment failure.
• Caution is advised when combining goserelin with drugs that affect bone metabolism, such as bisphosphonates, as it may influence bone density.
• Goserelin can enhance the effects of oral hypoglycemic agents and insulin, potentially causing hypoglycemia. Close monitoring is necessary.
• Interactions with hormonal contraceptives may occur, as goserelin can impact the efficacy of these medications.
• It may interact with certain immunosuppressants, affecting their effectiveness and increasing the risk of side effects.
• The use of goserelin with other medications that suppress the immune system should be closely monitored due to potential additive immunosuppressive effects.

Following are the food interactions for Goserelin 3.6mg Injection:

• Alcohol consumption should be avoided as it may interfere with hormone regulation and potentially reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can impact hormone levels and potentially interact with Goserelin's action.
• High-fat meals may slightly delay the absorption of the medication, but it is generally well-tolerated with or without food.
• Caffeine intake should be monitored as it can influence hormone levels and potentially affect the medication's efficacy.
• Avoid excessive sugar consumption as it may impact hormonal balance and potentially interfere with the medication's action.
• There is no significant interaction with dairy products, but a balanced diet is recommended for overall health.
• Stay well-hydrated by drinking adequate water to support overall health during the treatment.
• Follow dietary guidelines provided by your healthcare professional for optimal results.

Goserelin 3.6mg injection should be stored in a controlled environment, specifically at room temperature between 15-25°C (59-77°F). It is crucial to keep the injection in its original packaging, tightly sealed, and protected from light and moisture. Avoid freezing the medication or exposing it to excessive heat, as this can compromise its potency. Always check the expiration date before use and do not use the injection if it is expired. When it comes to disposal, do not dispose of the injection in regular household trash or flush it down the toilet. Instead, follow local guidelines for the safe disposal of medical waste, or consult your healthcare provider for specific instructions on how to properly dispose of the medication. Keep it out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Goserelin 3.6mg Injection:

• Administer the injection as directed by your doctor, typically every 28 days.
• Ensure the injection is given by a healthcare professional for proper administration.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Do not miss scheduled appointments for monitoring and follow-up during treatment.
• Report any unusual vaginal bleeding, persistent hot flashes, or signs of allergic reaction to your doctor.
• Store the injection as directed on the packaging, usually at room temperature away from light.
• Dispose of used needles and syringes safely in designated sharps containers.