Zolen (250/320mg) 90ml Suspension

Diloxanide Furoate primarily acts by interfering with the metabolic processes of amoebic parasites in the intestine. It selectively inhibits the enzyme dihydrofolate reductase in the amoebae, disrupting their ability to synthesize essential proteins and nucleic acids, leading to their death. On the other hand, Metronidazole Syrup/Suspension exerts its action by penetrating the cells of certain protozoa and anaerobic bacteria. Inside the cells, it disrupts DNA synthesis by interfering with DNA helices, causing a loss of helical structure and function, ultimately leading to the death of these microorganisms.

Antiprotozoal, Antibiotic

Suspension

The following are the uses of Diloxanide Furoate, Metronidazole Syrup/Suspension:

• Used for treating amebiasis (infections caused by amoebae), particularly effective against the cyst-forming parasite Entamoeba histolytica.
• Used for treating various anaerobic bacterial infections, including bacterial vaginosis, periodontal infections, and infections in the abdomen or gastrointestinal tract.
• Used for its ability to eliminate amoebic cysts from the intestinal tract, preventing the spread of amoebiasis.
• Used for managing symptoms like diarrhea and abdominal pain associated with amoebic infections.
• Used for treating children and adults, offering a syrup or suspension formulation for easier administration.
• Used for its broad-spectrum activity against various anaerobic pathogens and parasites.
• Used for its effectiveness in treating infections that are resistant to other antibiotics.
• Used for short-term treatment, typically lasting around 5 to 10 days, to minimize the risk of developing resistance.

In the case of an overdose of Diloxanide Furoate, prompt medical attention is necessary. Symptoms may include nausea, vomiting, and abdominal pain. For Metronidazole Syrup/Suspension overdose, individuals may experience dizziness, headaches, and a metallic taste. Quick action is required, including contacting a healthcare professional or poison control center for guidance on managing these overdoses effectively.

In the case of a missed dose of Diloxanide Furoate, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. Then, resume your regular dosing schedule. For Metronidazole Syrup/Suspension, if a dose is missed, take it as soon as possible, but if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to make up for a missed one.

To take Diloxanide Furoate and Metronidazole syrup/suspension, shake the bottle well, measure the prescribed dose with the provided measuring device, and administer it orally, following the dosage instructions from your healthcare provider or the product label, ensuring you take it as directed.

Following are the conditions or situations when Diloxanide Furoate and Metronidazole Syrup/Suspension should not be used:

• Allergy or hypersensitivity to Diloxanide Furoate or any ingredients in the medication.
• Not suitable for patients with severe kidney disease.
• Contraindicated in individuals with a history of blood disorders.
• Should not be used if the patient has shown an intolerance or reaction to Metronidazole or other nitroimidazole derivatives.
• Not recommended for patients with severe liver disease.
• Avoid use in patients with a central nervous system disease.
• Not suitable for children under 12 years of age.
• Should not be used during the first trimester of pregnancy and breastfeeding.
• Contraindicated in patients with a history of seizures or epilepsy.

The side effects of Diloxanide Furoate and Metronidazole Syrup/Suspension may include:

• Nausea and vomiting
• Loss of appetite
• Metallic taste in the mouth
• Dry mouth
• Diarrhea or constipation
• Dizziness or headache
• Skin rashes or itching

Following are the precautions and warnings for Diloxanide Furoate, Metronidazole Syrup/Suspension:

• This medication should not be used in patients with known allergies or hypersensitivity to Diloxanide Furoate or Metronidazole or any other ingredients in the syrup/suspension.
• It should be used with caution in patients with severe liver disease, as it is primarily metabolized in the liver.
• Avoid alcohol consumption during and for at least 48 hours after the completion of treatment with Metronidazole, as it may cause a disulfiram-like reaction.
• This medication may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for use in children under 12 years of age unless advised by a healthcare professional.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.
• Patients with gastrointestinal diseases should use this medication with caution, as it may cause gastrointestinal irritation.
• Always complete the full course of treatment to ensure the infection is completely eradicated and to prevent antibiotic resistance.

Following are the drug interactions for Diloxanide Furoate and Metronidazole Syrup/Suspension:

• Alcohol intake should be avoided as it may cause a disulfiram-like reaction with Metronidazole, leading to nausea, vomiting, and flushing.
• Diloxanide Furoate may decrease the effectiveness of hormonal contraceptives, so alternative birth control methods are recommended.
• Metronidazole can increase the anticoagulant effect of warfarin, requiring close monitoring of INR (International Normalized Ratio).
• Concomitant use with 5-fluorouracil or lithium may increase their toxicity, so close monitoring is necessary.
• Drugs that decrease gastric acidity, such as proton pump inhibitors, may reduce the absorption of Diloxanide Furoate.
• It may reduce the effectiveness of live bacterial vaccines; consider delaying vaccination until after treatment.
• Metronidazole can potentiate the effects of oral anticoagulants, requiring dosage adjustments.

Following are the food interactions for Diloxanide Furoate, Metronidazole Syrup/Suspension:

• Avoid consuming alcohol during and a few days after the treatment with this medication. Alcohol can cause an unpleasant reaction, including abdominal cramps, nausea, vomiting, headaches, and flushing.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Metronidazole, potentially leading to increased side effects.
• Dairy products like milk and yogurt can reduce the absorption of Metronidazole, so it is advisable to separate these by a few hours.
• Caffeinated beverages such as coffee and tea may increase the metabolism of Metronidazole, potentially reducing its effectiveness.
• Chocolate contains a compound that can potentially interact with Metronidazole, so it's best to avoid it during treatment.
• Foods rich in vitamin K, like leafy green vegetables, should be consumed in moderation as Metronidazole can interfere with blood clotting.
• Avoid sugary foods and drinks as they can promote the growth of bacteria in the mouth, potentially reducing the effectiveness of Metronidazole.
• There is no significant interaction with most regular diets, but it is advisable to maintain a balanced diet to support overall health during treatment.

Diloxanide Furoate and Metronidazole Syrup/Suspension should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and heat. The medication should be kept in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the effectiveness of the medication. When disposing of unused or expired medication, do not discard it in household waste or pour it down the drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment and prevent misuse. Keep the medication away from children and pets to avoid accidental ingestion.

Following are the quick tips for Diloxanide Furoate, Metronidazole Syrup/Suspension:

• Always take the medication as directed by your doctor or pharmacist.
• Measure the dose accurately using the measuring device provided.
• Take the syrup/suspension with a full glass of water to ensure proper swallowing.
• Avoid consuming alcohol while taking Metronidazole, as it may cause unpleasant side effects.
• Do not crush or chew the tablets; swallow them whole for best effect.
• Complete the full course of treatment, even if you feel better before it's finished.
• Store the medication at room temperature, away from moisture and direct sunlight.
• Inform your healthcare provider about any other medications you're taking to avoid potential interactions.