Zolint 60ml Suspension

Metronidazole and furazolidone work together through a multi-step mechanism of action in this dosage form. Metronidazole is an antibiotic penetrates bacterial and protozoal cells and is reduced by intracellular enzymes to form reactive metabolites. These metabolites bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, leading to cell death. Metronidazole is particularly effective against anaerobic bacteria and protozoa, such as Clostridium difficile and Giardia lamblia. Furazolidone is an antimicrobial agent inhibits monoamine oxidase and disrupts bacterial enzyme systems, leading to the production of toxic intermediates. These intermediates damage the bacterial DNA, ultimately resulting in bacterial death.

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Antibiotic

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Syrup/Suspension

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This medication is used for:

• Treating gastrointestinal disorders
• Reducing nausea and vomiting
• Supporting digestive health
• Managing symptoms related to motion sickness

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Zolint dosage for the indication of bacterial infections, duration of 5-10 days:

• Adults - 15 ml 3 times daily.
• Children - 5-10 ml 3 times daily.

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Overdose can lead to gastrointestinal distress and neurological symptoms. Seek medical help for symptomatic treatment.

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If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

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Metronidazole is taken orally with food. Furazolidone is typically taken with meals. Complete the prescribed course.

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Metronidazole, Furazolidone should not be used if:

• Hypersensitivity
• Severe liver impairment
• Alcohol consumption (disulfiram-like reaction)

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Possible side effects of Metronidazole and Furazolidone include:

• Nausea
• Vomiting
• Diarrhea
• Metallic taste
• Allergic reactions

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The warnings and precautions for Metronidazole and Furazolidone are:

• Patient with a history of severe skin reactions or hypersensitivity to nitroimidazole derivatives
• History of liver disease, particularly if severe
• Patients with neurological disorders (e.g. seizures)
• Avoid alcohol during and for 48 hours after treatment with Metronidazole
• Patients with blood dyscrasias
• Pregnancy and lactation (particularly during the first trimester)

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The drug interactions with metronidazole and furazolidone include:

• Metronidazole- Alcohol – Can cause a disulfiram-like reaction.
• Furazolidone- MAO Inhibitors – Can cause hypertensive reactions.

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For Metronidazole and Furazolidone, food interactions that should be considered are:

• Alcohol should be avoided during treatment as it may cause severe reactions.
• Taking with food may help reduce gastrointestinal upset.

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Metronidazole should be stored at room temperature, away from light and moisture. Furazolidone should also be kept at room temperature, protected from light and moisture. Both medications should be kept in their original containers and out of reach of children. Dispose of expired or unused medications properly, following local disposal guidelines or using a drug take-back program.

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