Zolint 60ml syp

Metronidazole and Furazolidone are both antimicrobial agents that primarily target anaerobic bacteria and protozoa. Metronidazole's mechanism of action involves disrupting the DNA structure of susceptible organisms. It is selectively taken up by anaerobic bacteria and protozoa, where it is then reduced to metabolites that bind to DNA, causing DNA strand breaks and inhibition of DNA synthesis, ultimately leading to cell death. Furazolidone, on the other hand, acts by interfering with nucleic acid synthesis. It inhibits the action of bacterial enzymes involved in DNA replication, specifically DNA-dependent RNA polymerase, thereby preventing RNA synthesis and subsequent protein synthesis, which is essential for bacterial growth and survival.

Antiprotozoal/Antibacterial

Suspension

The following are the uses of Metronidazole, Furazolidone Syrup/Suspension:

• Used for treating gastrointestinal infections caused by bacteria and protozoa, such as giardiasis and amoebiasis.
• Used for controlling diarrhea and gastrointestinal inflammation associated with bacterial and parasitic infections.
• Used for managing infections caused by anaerobic bacteria, particularly in the gastrointestinal tract.
• Used for treating infections caused by certain parasites, including Trichomonas vaginalis.
• Used for reducing the severity of symptoms in gastrointestinal infections, such as abdominal pain and cramping.
• Used for preventing the spread of certain parasitic infections in the gastrointestinal tract.
• Used for providing symptomatic relief in cases of traveler's diarrhea caused by bacterial or parasitic pathogens.

In the case of an overdose of Metronidazole or Furazolidone Syrup/Suspension, the primary concern is the potential for severe gastrointestinal symptoms. Nausea, vomiting, and abdominal pain may occur, and in more serious cases, seizures and neurological issues can develop. It is important to seek medical assistance promptly, as treatment may involve managing these symptoms and providing supportive care to prevent further complications, especially in children or individuals with pre-existing health conditions.

In the case of a missed dose of Metronidazole, it is recommended to take the missed dose as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Furazolidone Syrup/Suspension, if a dose is missed, take it as soon as possible. If it is near the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

To administer Metronidazole, Furazolidone Syrup/Suspension, shake the bottle well, use an oral syringe or measuring cup to draw the prescribed amount, and give it to your child by mouth, ensuring it is taken as directed by the healthcare provider, typically three times a day with or without food.

Here are the conditions or situations when Metronidazole, Furazolidone Syrup/Suspension should not be used:

• Should not be used in patients with a known allergy to Metronidazole, Furazolidone, or other nitroimidazole derivatives.
• Contraindicated in patients with a history of blood disorders or central nervous system diseases.
• Not recommended for individuals with liver or kidney disease.
• Should be avoided during the first trimester of pregnancy and breastfeeding.
• Do not use in patients with a history of seizures or epilepsy.
• Contraindicated in patients with a history of severe gastrointestinal diseases.
• Not suitable for individuals with a history of porphyria.
• Should not be administered to patients with a history of peripheral neuropathy.
• Avoid in patients with a known sensitivity to any of the excipients in the suspension/syrup formulation.
• Discontinue use if signs of serious skin reactions or allergic reactions occur.

The side effects of Metronidazole, Furazolidone Syrup/Suspension may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Darkening of urine
• Metallic taste in the mouth
• Dizziness or headaches
• Skin rashes or itching

Following are the precautions and warnings for Metronidazole, Furazolidone Syrup/Suspension:

• This medication should not be used in patients with a known hypersensitivity or allergy to Metronidazole or Furazolidone.
• Not recommended for individuals with a history of blood disorders, as it may cause bone marrow depression.
• Avoid alcohol consumption during and for at least 72 hours after treatment, as it may cause a disulfiram-like reaction with symptoms such as flushing, nausea, and vomiting.
• Patients with liver or kidney disease should exercise caution and consult a healthcare professional before use, as dosage adjustments may be necessary.
• Metronidazole may cause dizziness or lightheadedness; patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Furazolidone may cause a harmless darkening of urine, but it can discolor contact lenses, so lens wearers should be cautious.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks, as determined by a healthcare professional.
• Keep out of reach of children and store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Metronidazole, Furazolidone Syrup/Suspension:

• Alcohol consumption should be avoided as it can cause a disulfiram-like reaction, leading to nausea, vomiting, flushing, and headaches.
• Concomitant use with busulfan, lithium, or 5-fluorouracil may increase the risk of toxicity due to altered metabolism.
• It can interact with anticoagulants like warfarin, potentially affecting blood clotting and requiring close monitoring of INR (International Normalized Ratio).
• Phenytoin, phenobarbital, and rifampicin may reduce the effectiveness of this medication.
• Prothrombin time/INR should be monitored when used with oral anticoagulants.
• This medication may decrease the effectiveness of hormonal contraceptives, requiring additional birth control methods.
• It may also interact with other antibiotics like amoxicillin and macrolides, potentially reducing their efficacy.

Following are the food interactions for Metronidazole, Furazolidone Syrup/Suspension:

• Avoid consuming alcohol while taking this medication, as it can cause a severe reaction, including symptoms like nausea, vomiting, flushing, headache, and increased heart rate.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, potentially leading to increased side effects.
• Dairy products like milk, yogurt, and cheese may reduce the absorption of the medication, so it is advisable to take the medication at least 1-2 hours before or after consuming dairy.
• Foods high in tyramine (aged cheeses, cured meats, fermented foods) should be avoided as they may interact with the medication, causing a sudden increase in blood pressure.
• Caffeinated beverages like coffee, tea, and energy drinks may enhance the stimulant effects of the medication, potentially leading to increased anxiety or insomnia.
• Avoid high-fat meals as they can delay the absorption of the medication, leading to reduced effectiveness.
• Vitamin and mineral supplements, especially those containing iron, calcium, or magnesium, can interfere with the absorption of the medication, so it is best to take them at different times.
• Certain foods like beans, cruciferous vegetables (broccoli, cabbage), and high-fiber foods may affect the medication's metabolism and should be consumed in moderation.

Metronidazole and Furazolidone Syrup/Suspension should be stored at room temperature, preferably between 68°F and 77°F (20°C and 25°C), in a dry place away from light and moisture. Always keep the medication in its original container with the cap tightly closed to maintain its integrity. Do not store it in the bathroom or kitchen, as these areas are prone to temperature fluctuations. When disposing of the medication, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for advice on safe disposal practices. Keep this medication safely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Metronidazole, Furazolidone Syrup/Suspension:

• Consult your doctor before use, especially if you have any allergies or medical conditions.
• Administer the syrup as directed by your healthcare professional for effective treatment.
• Shake the bottle vigorously prior to use to ensure uniformity.
• Administer the prescribed dose using the measuring cup provided for accurate dosage.
• Maintain a consistent dosing schedule to maximize therapeutic benefits.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Always read the patient information leaflet provided with the medication for detailed instructions.