Zopan DS 200 Tablets

Domperidone primarily acts as a dopamine antagonist, specifically blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain. By inhibiting dopamine receptors, domperidone reduces the stimulation of the CTZ, which is responsible for triggering nausea and vomiting. This mechanism helps to suppress the feeling of nausea and prevents vomiting. On the other hand, Omeprazole, a proton pump inhibitor, works by irreversibly inhibiting the hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, also known as the gastric proton pump. This enzyme system is responsible for the final step of gastric acid secretion in the stomach. By binding to and blocking the proton pump, omeprazole effectively suppresses gastric acid production, leading to a reduction in gastric acidity and creating a more favorable environment for the healing of acid-related conditions.

Domperidone, Omeprazole

Prokinetic, Proton Pump Inhibitor.

Tablet

The following are the uses of Domperidone, Omeprazole Tablet:

• Used for controlling nausea and vomiting.
• Used to treat acid reflux and promote gastric emptying.
• Effective in managing gastroparesis and improving digestion.
• Helps reduce stomach acid production, relieving heartburn and indigestion.
• Useful in treating gastrointestinal motility disorders.
• Can be utilized to prevent and treat nausea caused by certain medications.
• Provides relief for upper gastrointestinal tract symptoms.

In the case of an overdose of Domperidone and Omeprazole Tablets, the severity of symptoms can vary. Nausea, vomiting, and abdominal discomfort are common immediate effects. However, more serious consequences may include cardiac arrhythmias, prolonged QT intervals, and seizures. It is crucial to seek medical advice promptly if an overdose is suspected, as early intervention can help manage these potentially harmful effects effectively.

In the case of a missed dose of Domperidone, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Omeprazole, if you miss a dose, take it as soon as you remember, but if it is close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. It is important not to take extra medication to compensate for a missed dose.

To take Domperidone and Omeprazole tablets, swallow the tablets whole with a full glass of water, preferably in the morning before food, following the dosage instructions provided by your healthcare professional, ensuring you adhere to the prescribed frequency and duration of the medication.

Following are the conditions/situations when Domperidone and Omeprazole Tablet should not be used:

• Should not be used in individuals with a known allergy to Domperidone, Omeprazole, or any of the tablet's components.
• Contraindicated in patients with a history of long QT syndrome or irregular heartbeats.
• Not suitable for individuals with severe kidney or liver impairment.
• Should not be used if there is evidence of mechanical obstruction of the gastrointestinal tract.
• Contraindicated in patients with a history of pheochromocytoma.
• Not recommended for individuals with low magnesium levels in the blood.
• Should be avoided in patients with severe gastrointestinal conditions such as bleeding, tumors, or perforation.
• Contraindicated in patients with a history of hypersensitivity reactions to similar medications.

The side effects of Domperidone, Omeprazole Tablet may include:

• Gastrointestinal discomfort (such as nausea, vomiting, or stomach pain)
• Dry mouth
• Headache
• Diarrhea
• Dizziness
• Fatigue or weakness
• Skin rashes
• Irregular heart rhythm

Following are the precautions and warnings for Domperidone, Omeprazole Tablet:

• This medication should be used with caution in patients with underlying heart conditions, as Domperidone can affect heart rhythm.
• Patients with liver problems should exercise caution, as Omeprazole is metabolized by the liver and dosage adjustments may be necessary.
• Not recommended for individuals with a known allergy to either Domperidone or Omeprazole, or any other ingredients in the tablet.
• May cause dizziness and blurred vision; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more susceptible to side effects, particularly those related to Domperidone's effects on the central nervous system.
• Long-term use of Omeprazole may lead to decreased absorption of certain nutrients; regular monitoring of vitamin B12 and magnesium levels is advised.
• Patients should inform their healthcare provider about all medications they are currently taking to avoid potential drug interactions.

Following are the drug interactions for Domperidone and Omeprazole Tablet:

• Domperidone may interact with drugs metabolized by CYP3A4, such as ketoconazole, erythromycin, and verapamil, leading to increased domperidone levels.
• It can also increase the effects of certain opioid medications, like codeine and hydrocodone, by enhancing their absorption.
• Omeprazole can reduce the absorption of drugs like ketoconazole, atazanavir, and digoxin, requiring monitoring and dosage adjustments.
• It may also decrease the effectiveness of clopidogrel, a blood thinner, requiring alternative antiplatelet therapy.
• Concomitant use with diazepam or midazolam can result in increased sedation and respiratory depression.
• Antifungal medications like itraconazole and voriconazole may increase omeprazole levels, necessitating dose reduction.
• Drugs that rely on gastric pH for activation, such as ampicillin esters, may have reduced efficacy when taken with omeprazole.

Following are the food interactions for Domperidone, Omeprazole Tablet:

• Avoid grapefruit and grapefruit juice as they can increase the concentration of Domperidone, potentially leading to elevated side effects.
• Alcohol consumption should be limited as it may enhance the sedative effects of Domperidone.
• Foods that are highly acidic or spicy may irritate the stomach and should be consumed with caution.
• Omeprazole absorption can be reduced by certain foods, so it is best taken on an empty stomach.
• Avoid high-fat meals as they may delay the absorption of Omeprazole.
• Dairy products can potentially decrease the effectiveness of Omeprazole, so consider separating them by a few hours.
• Some foods like broccoli, Brussels sprouts, and cauliflower contain compounds that may interfere with Omeprazole's metabolism.

Domperidone, Omeprazole Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to avoid storing the tablets in the bathroom or near heat sources, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired medication responsibly; do not flush or pour them into water sources. Consult your pharmacist for guidance on safe disposal practices, and always keep medications away from children to prevent accidental consumption. Proper storage and disposal practices are essential for maintaining the quality and safety of Domperidone, Omeprazole Tablets.

Following are the quick tips for Domperidone, Omeprazole Tablet:

• Take the tablet as directed by your doctor, usually before meals.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Avoid drinking alcohol as it may worsen side effects.
• Inform your doctor if you have any liver or kidney problems before taking this medication.
• Do not take this medication if you are allergic to any of its ingredients.
• Store in a cool, dry place away from direct sunlight.
• Do not share this medication with others, even if they have similar symptoms.