ZOSTREX GEL 25G

Capsaicin, the active component in Capsaicin Gel, acts by selectively binding to and activating transient receptor potential vanilloid subtype 1 (TRPV1) receptors, which are predominantly found in sensory neurons. Upon application, capsaicin causes a rapid excitation of these sensory nerves, leading to a sensation of burning or warmth. However, with continued or repeated exposure, capsaicin induces a process known as defunctionalization, where it depletes the nerve endings of their neurotransmitters and causes a reversible loss of sensation. This effect is achieved through a reduction in the concentration of substance P, a neuropeptide involved in pain transmission, at the nerve terminals. As a result, capsaicin gel effectively modulates pain signaling, providing analgesic effects in various conditions.

Capsaicin

Capsicum/Capsaicin (topical).

Gel

The following are the uses of Capsaicin Gel:

• Used for relieving muscle or joint pain.
• Used for reducing inflammation and providing temporary pain relief.
• Used for treating conditions like arthritis, back pain, and nerve pain.
• Used for post-operative pain management to aid in recovery.
• Used for topical application to improve blood circulation in the affected area.
• Used for managing chronic pain conditions under medical supervision.
• Used for providing localized pain relief without systemic side effects.
• Used for sports-related injuries to accelerate healing and reduce discomfort.

In the case of an overdose of Capsaicin Gel, it is important to recognize the potential symptoms, which may include severe skin irritation, burning sensations, and redness. If ingested, it can lead to gastrointestinal issues like nausea, vomiting, and stomach pain. Promptly seek medical advice and ensure the affected area is thoroughly washed with mild soap and water to minimize discomfort. It is crucial to exercise caution and adhere to the recommended dosage guidelines to prevent such incidents.

In the case of a missed dose of Capsaicin Gel, it is generally advised to apply the gel as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply extra gel to make up for the missed dose, as this may increase the risk of skin irritation. It's important to maintain a consistent application routine for the best therapeutic effect. If you frequently miss doses, consider setting reminders or asking someone to help you stay on track.

To apply the Capsaicin Gel, clean and dry the affected skin area, then gently massage a thin layer of the gel onto the skin, ensuring you follow the recommended dosage instructions provided by your healthcare professional.

Here is a list of conditions and situations when Capsaicin Gel should not be used:

• Avoid using on open wounds, cuts, or severely damaged skin.
• Not recommended for individuals with a known allergy to Capsaicin or related compounds.
• Do not apply near eyes, nose, mouth, or other sensitive areas.
• Should not be used on skin areas with eczema, psoriasis, or other skin conditions without medical advice.
• Avoid using Capsaicin Gel on skin that will be exposed to extreme heat or cold after application.
• Not suitable for children without medical supervision and guidance.
• Do not use on skin that is already irritated or inflamed due to other topical medications.
• Contraindicated in individuals with a history of severe skin reactions or sensitivity to topical treatments.
• Avoid using under tight-fitting clothing or bandages as it may increase the risk of skin irritation.
• Do not use Capsaicin Gel on skin that has been treated with other skin treatments like chemical peels or laser therapy without medical advice.

The side effects of Capsaicin Gel may include:

• Skin irritation and burning sensation at the application site
• Redness and itching
• Localized swelling
• Watery eyes and runny nose (if used near the eyes or nose)
• Coughing or sneezing (if accidentally inhaled)
• Temporary skin discoloration
• Allergic reactions in rare cases

Following are the precautions and warnings for Capsaicin Gel:

• Avoid contact with eyes, nose, mouth, and other sensitive areas. Wash hands thoroughly after application to avoid accidental transfer.
• Perform a skin patch test before using the gel to ensure you don't have an allergic reaction.
• Do not apply to open wounds, cuts, or irritated skin.
• It may cause a temporary burning sensation or skin redness, which is normal. Discontinue use if severe irritation occurs.
• Wash hands immediately after application, especially before touching the eyes or face.
• Keep out of reach of children and pets. Store in a cool, dry place away from direct sunlight.
• Consult a healthcare professional if you are pregnant, breastfeeding, or have any underlying medical conditions before using this product.

Following are the drug interactions for Capsaicin Gel:

• Capsaicin Gel may enhance the absorption of other topical medications when applied simultaneously, leading to increased effects.
• When used with other medications that contain capsaicin, there is a potential for increased skin irritation and sensitivity.
• It can interact with local anesthetics, potentially reducing their effectiveness.
• Antihistamines and corticosteroids may decrease the effectiveness of Capsaicin Gel when used concurrently.
• Certain medications like lidocaine or prilocaine can increase the risk of skin reactions when combined with Capsaicin Gel.
• The use of Capsaicin Gel with other pain-relieving medications, such as opioids, may result in altered pain perception.
• Some medications affecting blood circulation, like vasodilators, might influence the distribution of Capsaicin Gel.

Following are the food interactions to be aware of when using Capsaicin Gel:

• Capsaicin Gel should not be applied near the eyes, nose, or mouth to avoid accidental ingestion or contact with sensitive areas.
• Wash your hands thoroughly after applying the gel to avoid transferring it to other body parts or to food.
• Avoid touching or rubbing your eyes after handling the gel, as it can cause irritation and burning sensations.
• Be cautious when handling spicy foods or peppers while using Capsaicin Gel, as it can enhance the burning sensation and potentially cause skin irritation.
• It is generally safe to consume spicy foods while using the gel, but individual tolerance may vary, and it's best to monitor your body's response.
• There is no specific food restriction with Capsaicin Gel, but maintaining a healthy diet and staying hydrated is always recommended for overall well-being.
• Some individuals may experience increased sensitivity to hot or spicy foods while using Capsaicin Gel, so it's advisable to adjust your diet accordingly.
• Consult your healthcare provider if you have concerns about specific food interactions or if you experience any unusual symptoms related to food consumption while using the gel.

The proper storage and disposal of Capsaicin Gel are crucial for safety and environmental considerations. Store the gel in a cool, dry area at room temperature, ensuring it remains protected from sunlight and moisture. Keep the gel in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid extreme temperatures, such as heat from stoves or radiators, as they can impact the gel's stability. Regularly check the expiration date, and if the gel is past its prime, dispose of it responsibly. Never flush it down the toilet or pour it into drains; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Additionally, keep the gel securely stored away from children to prevent accidental exposure.

Following are the quick tips for Capsaicin Gel:

• Wash your hands thoroughly before and after applying the gel to avoid irritation in sensitive areas.
• Apply a thin layer of the gel to the affected area and gently massage it into the skin.
• Use the gel as directed by your healthcare provider, typically 3-4 times a day for maximum effectiveness.
• After application, avoid touching your eyes or sensitive areas to prevent irritation.
• Do not apply the gel to broken or irritated skin, and discontinue use if you experience severe burning or skin reactions.
• Ensure you allow sufficient time for the gel to be absorbed before dressing to prevent staining clothes.
• Store the gel at room temperature and keep it away from direct sunlight or extreme temperatures.