ZYFURON SYP

Furazolidone, the active ingredient in Furazolidone Syrup/Suspension, primarily acts as a bactericidal and antiprotozoal agent. It exerts its antimicrobial effect by interfering with nucleic acid metabolism and protein synthesis in susceptible microorganisms. Furazolidone inhibits the synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA), thereby disrupting the synthesis of nucleic acids and proteins essential for bacterial growth and survival. This mechanism of action contributes to its effectiveness against a range of bacteria and protozoa, making it useful in treating various infections.

Furazolidone

Antibiotic

Suspension

The following are the uses of Furazolidone Syrup/Suspension:

• Used for treating diarrhea in adults and children, particularly when caused by bacteria or protozoa.
• Used for controlling and managing infectious diarrhea, helping to reduce the duration and severity of symptoms.
• Used for traveler's diarrhea, offering quick relief and preventing further complications.
• Used for treating enteric fever (typhoid fever) in combination with other antibiotics.
• Used for its antibacterial properties to combat various gastrointestinal infections.
• Used for its anti-inflammatory effects, helping to reduce inflammation in the gut.
• Used for pediatric cases, providing a safe and effective treatment option for children.
• Used for its broad-spectrum activity against a range of gastrointestinal pathogens.

In the case of an overdose of Furazolidone Syrup/Suspension, it is important to act swiftly. The symptoms may include severe nausea, vomiting, dizziness, and a rapid heartbeat. Promptly seek medical advice or contact a poison control center for guidance. They will provide specific instructions to manage the overdose, which may include inducing vomiting or administering activated charcoal to absorb the excess medication.

In the case of a missed dose of Furazolidone Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your medication schedule. It is crucial to maintain a consistent medication routine for the best treatment outcomes.

To administer Furazolidone Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and take it orally, preferably after meals, as directed by your healthcare professional, ensuring you follow the recommended dosage and duration of treatment.

Here are the situations when Furazolidone Syrup/Suspension should not be used:

• Avoid using in individuals with a known allergy or hypersensitivity to Furazolidone or any of its components.
• Not suitable for individuals with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Contraindicated in patients with a history of narrow-angle glaucoma.
• Should not be used in patients with severe cardiovascular disease or hypertension.
• Not recommended for individuals with a history of seizures or epilepsy.
• Avoid using in patients with severe liver or kidney impairment.
• Furazolidone is contraindicated during the breastfeeding period.
• Should not be administered to infants under 2 months of age.

The side effects of Furazolidone Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Headache
• Dizziness
• Skin rash or itching
• Discoloration of the urine (it may appear dark yellow or brown)
• Central nervous system effects like anxiety, insomnia, and restlessness.

Following are the precautions and warnings for Furazolidone Syrup/Suspension:

• Not recommended for individuals with a known allergy to Furazolidone or any of its ingredients.
• Furazolidone should be used with caution in patients with a history of liver or kidney disease, as it may require dosage adjustments.
• Avoid alcohol consumption while taking this medication, as it can increase the risk of side effects.
• Patients with diabetes should be cautious, as Furazolidone may interfere with blood sugar control.
• This medication may cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them.
• Do not use Furazolidone if you are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may pose risks to the fetus or infant.
• Furazolidone should be used with caution in children, and the dosage should be carefully determined by a healthcare professional.

Following are the drug interactions for Furazolidone Syrup/Suspension:

• Alcohol consumption should be avoided as it can increase the risk of adverse effects, especially central nervous system side effects like dizziness and drowsiness.
• It may interact with adrenergic agonists (e.g., epinephrine, norepinephrine) and adrenergic antagonists (e.g., beta-blockers), leading to increased or decreased blood pressure effects.
• Furazolidone can inhibit the metabolism of drugs metabolized by monoamine oxidase (MAO), potentially causing serious interactions with MAO inhibitors.
• Serotonin syndrome risk is increased when combined with other serotonergic agents like selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs).
• Drugs that affect blood clotting, such as anticoagulants (e.g., warfarin), may have enhanced effects when used with Furazolidone, requiring close monitoring.
• The effectiveness of thyroid medications (e.g., levothyroxine) may be reduced, requiring dosage adjustments.
• It can also inhibit the metabolism of drugs metabolized by the liver's cytochrome P450 enzymes, potentially affecting the levels of medications like certain antidepressants and antipsychotics.

Following are the food interactions for Furazolidone Syrup/Suspension:

• Avoid consuming tyramine-rich foods like aged cheeses, cured meats, fermented foods, and certain types of beans, as they can interact with Furazolidone, leading to a dangerous spike in blood pressure.
• Foods high in monoamine oxidase inhibitors (MAOIs) such as soy products, fermented foods, and certain legumes should be avoided to prevent potential drug interactions and side effects.
• Restrict the consumption of high-protein foods as they can reduce the absorption of Furazolidone, making the medication less effective.
• Grapefruit and grapefruit juice are to be avoided as they may interfere with the metabolism of Furazolidone, potentially increasing its levels in the body and the risk of side effects.
• Alcoholic beverages should be limited or avoided as they can increase the risk of side effects such as nausea, dizziness, and headache when combined with Furazolidone.
• Caffeinated drinks like coffee, tea, and energy drinks may enhance the stimulant effects of Furazolidone, potentially causing jitters, rapid heartbeat, or insomnia.
• Avoid high-fat meals as they may slow down the absorption of Furazolidone, delaying its therapeutic effect.
• Always follow your healthcare provider's instructions regarding dietary restrictions and medication intake.

Furazolidone Syrup/Suspension should be stored with caution, ensuring it is kept in a secure location away from children and pets. The ideal storage conditions are at room temperature, between 68°F and 77°F (20°C and 25°C), in a cool and dry place. Protect the medication from direct sunlight, heat, and moisture, and do not store it in the bathroom or kitchen to prevent exposure to temperature fluctuations. Always keep the syrup in its original container, tightly sealed, to maintain its integrity. When disposing of any unused or expired medication, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for safe disposal methods.

Following are the quick tips for Furazolidone Syrup/Suspension:

• Follow the prescription and complete the full course as directed by your doctor.
• Shake the bottle vigorously before each use to ensure proper mixing.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Avoid consuming alcohol while taking this medication to prevent adverse interactions.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication, as it may affect its potency.
• Dispose of any unused or expired medication safely and responsibly.