Zynol (100mg) 50 Tablets

Allopurinol 100mg tablets work by inhibiting the enzyme xanthine oxidase, which is responsible for the production of uric acid in the body. This medication blocks the conversion of xanthine to uric acid, thereby reducing the levels of uric acid in the blood and urine. The primary mechanism of action is to decrease the production of uric acid, which helps prevent the formation of urate crystals. By inhibiting xanthine oxidase, allopurinol disrupts the purine metabolism pathway, leading to lower uric acid concentrations. This is particularly important in the management of conditions such as gout and certain types of kidney stones, where elevated uric acid levels can cause inflammation, pain, and tissue damage.

Allopurinol 100mg

Xanthine Oxidase Inhibitor.

Tablet

The following are the uses of Allopurinol 100mg Tablet:

• Used for lowering high uric acid levels in the blood, which can cause gout and kidney stones.
• Used to treat gout attacks and prevent future flare-ups by reducing uric acid production.
• Used for managing chronic gout and preventing joint damage.
• Used to alleviate joint pain, swelling, and inflammation associated with gout.
• Used to improve kidney function in patients with uric acid-related kidney issues.
• Used as a long-term treatment to maintain normal uric acid levels.
• Used to reduce the risk of gout complications and improve overall quality of life.

In the case of an overdose of Allopurinol 100mg Tablets, individuals may experience severe adverse effects. Symptoms can include gastrointestinal distress, such as nausea, vomiting, and diarrhea, as well as potential kidney damage and a decrease in white blood cell count. Immediate medical intervention is necessary, and healthcare professionals should be contacted without delay. Prompt treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and prevent further complications.

In the case of a missed dose of Allopurinol 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication. It is advisable to set reminders or use a pill organizer to help you stay on track with your medication regimen.

To take Allopurinol 100mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Allopurinol 100mg Tablet should not be taken:

• Should not be taken by individuals who have a known allergy to Allopurinol or any of its ingredients.
• Contraindicated in patients with a history of hypersensitivity or severe reactions to any purine analogues.
• Not recommended for patients with severe kidney impairment or kidney failure.
• Should not be used during an acute attack of gout.
• Contraindicated in patients with a rare hereditary problem of fructose intolerance.
• Not suitable for individuals with a history of liver disease or severe liver impairment.
• Should be avoided in patients with heart disease or blood vessel disease.
• Discontinue use if severe skin reactions or allergic reactions occur.

The side effects of Allopurinol 100mg Tablet may include:

• Skin rash or itching
• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Fatigue or weakness
• Joint pain or muscle aches
• Changes in liver function tests

Following are the precautions and warnings for Allopurinol 100mg Tablet:

• Allopurinol may cause severe allergic reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Discontinue use at the first sign of a skin rash or any allergic reaction.
• Regular monitoring of kidney and liver function is necessary during treatment. Inform your doctor if you have a history of kidney or liver disease.
• This medication can cause gastrointestinal issues such as nausea, vomiting, and diarrhea. Contact your doctor if these symptoms become severe.
• Allopurinol may increase the risk of bleeding. Patients with a history of bleeding disorders or those taking anticoagulant medications should be closely monitored.
• Patients with a history of heart disease or hypertension should be cautious, as Allopurinol can affect blood pressure and cardiovascular health.
• Avoid alcohol consumption while taking Allopurinol, as it may increase the risk of liver damage and other side effects.
• Inform your healthcare provider about all the medications you are currently taking to prevent potential drug interactions.
• Allopurinol may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medication affects you.

Following are the drug interactions for Allopurinol 100mg Tablet:

• Thiazide diuretics, when used with Allopurinol, may increase the risk of hypersensitivity reactions and reduce the effectiveness of Allopurinol.
• Allopurinol can increase the blood levels of azathioprine and mercaptopurine, leading to increased toxicity. Close monitoring is required.
• The combination of Allopurinol and ampicillin increases the risk of developing a skin rash.
• When used with cyclophosphamide, Allopurinol may lead to increased bone marrow suppression.
• Warfarin interaction with Allopurinol can result in altered anticoagulant effects, requiring close monitoring of INR (International Normalized Ratio).
• Concomitant use with didanosine may increase the risk of pancreatitis and liver toxicity.
• Allopurinol can increase the concentration of theophylline, a bronchodilator, potentially leading to theophylline toxicity.

Following are the food interactions for Allopurinol 100mg Tablet:

• Alcohol consumption should be limited or avoided as it can increase the risk of liver problems and may also increase the likelihood of an allergic reaction.
• Avoid grapefruit and grapefruit juice as they can increase the levels of Allopurinol in the blood, potentially leading to increased side effects.
• High-purine foods like organ meats, anchovies, sardines, and game meats should be limited as they can increase uric acid production, counteracting the medication's effects.
• Vitamin C-rich foods such as citrus fruits, berries, and leafy greens may enhance the effectiveness of Allopurinol by promoting uric acid excretion.
• Maintaining a balanced diet with moderate protein intake is essential, as high-protein diets can increase uric acid levels, reducing the medication's efficacy.
• Staying well-hydrated by drinking plenty of water can help in flushing out uric acid crystals and support the medication's action.
• Avoid fasting or extreme diets, as they can disrupt the body's normal metabolic processes and potentially affect the medication's effectiveness.
• Certain high-fat meals might delay the absorption of Allopurinol, but this effect is generally not significant enough to require timing adjustments.

Allopurinol 100mg Tablets should be stored in a secure and dry location, away from moisture and direct sunlight. Maintain a consistent room temperature for storage, avoiding extreme heat or cold. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in bathrooms or near heat-emitting appliances. Always check the expiration date, and if the medication has passed its expiry, do not use it and dispose of it appropriately. For proper disposal methods, consult your pharmacist or local waste management guidelines. Ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Allopurinol 100mg Tablet:

• Start with a low dose and gradually increase as directed by your doctor.
• Take the tablet with a full glass of water to aid absorption.
• Avoid taking antacids or dairy products within 1 hour of taking the tablet.
• Maintain a consistent fluid intake to prevent kidney stone formation.
• Do not take this medication if you are allergic to any of its ingredients.
• Regularly monitor your uric acid levels as advised by your healthcare provider.
• Store the tablets in a cool, dry place, away from direct sunlight.