Zynol (300mg) 20 Tablets

Allopurinol 300mg tablets work by inhibiting the enzyme xanthine oxidase, which is responsible for the production of uric acid in the body. This medication blocks the conversion of xanthine to uric acid, thereby reducing the overall production of uric acid. By lowering uric acid levels, allopurinol helps prevent the formation of urate crystals, which are the cause of gout and certain types of kidney stones. Specifically, allopurinol inhibits the oxidation of hypoxanthine to xanthine and the subsequent oxidation of xanthine to uric acid, leading to decreased serum and urinary uric acid concentrations. This mechanism of action makes allopurinol effective in managing conditions where uric acid buildup is a concern.

Allopurinol 300mg

Xanthine Oxidase Inhibitor

Tablet

The following are the uses of Allopurinol 300mg Tablet:

• Used for lowering high uric acid levels in the blood, a condition known as hyperuricemia.
• Used for preventing gout attacks by reducing the production of uric acid.
• Used for managing gouty arthritis, helping to reduce inflammation and pain during flare-ups.
• Used for treating kidney stones caused by high uric acid levels.
• Used for preventing kidney damage associated with long-term gout.
• Used for managing certain types of cancer-related conditions, such as tumor lysis syndrome.
• Used for reducing the risk of gout complications, such as joint damage and tophi formation.

In the case of an overdose of Allopurinol 300mg Tablets, it is important to recognize the potential severity of this situation. Overconsumption may lead to increased side effects, including severe skin reactions, allergic responses, and gastrointestinal issues. If an overdose is suspected, prompt medical intervention is necessary. Medical professionals should be contacted immediately for guidance and treatment, as they can provide the appropriate care and monitor for any adverse reactions. Quick action can help mitigate the risks associated with Allopurinol overdose.

In the case of a missed dose of Allopurinol 300mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss several doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is crucial to adhere to the prescribed treatment plan for the medication to be effective.

To take Allopurinol 300mg Tablet, swallow the tablet whole with a full glass of water, preferably during or after a meal, once daily or as directed by your healthcare provider.

Following are the conditions/situations when Allopurinol 300mg Tablet should not be taken:

• Must not be taken by individuals who are allergic to Allopurinol or any of its ingredients.
• Not suitable for patients with a history of liver disease or impaired liver function.
• Should be avoided during pregnancy or breastfeeding.
• Not recommended for individuals with kidney stones or a history of kidney disease.
• Should not be used in patients with high levels of uric acid due to cancer or chemotherapy.
• Contraindicated in patients with a rare inherited condition known as Lesch-Nyhan syndrome.
• Not suitable for those with a history of allergic reactions to sulfonamides or penicillins, as cross-sensitivity may occur.
• Should be used with caution and avoided if possible in patients with a history of heart disease or stroke.
• Must not be taken by individuals with a known blood disorder called porphyria.

The side effects of Allopurinol 300mg Tablet may include:

• Skin rash or itching
• Nausea and vomiting
• Diarrhea
• Stomach pain
• Headache
• Dizziness
• Muscle or joint pain
• Unusual tiredness or weakness

Following are the precautions and warnings for Allopurinol 300mg Tablet:

• Not recommended for individuals with a known hypersensitivity or severe allergic reaction to Allopurinol or any of its ingredients.
• Patients with kidney or liver disease should use with caution, as dosage adjustments might be necessary.
• May cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Avoid alcohol consumption while taking Allopurinol as it may increase the risk of certain side effects.
• Regular monitoring of kidney function and blood cell counts is advised during long-term treatment.
• Patients with a history of liver disease should have their liver function monitored while on this medication.
• Allopurinol may interact with other medications; inform your doctor about all medications you are currently taking.
• Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Following are the drug interactions for Allopurinol 300mg Tablet:

• Allopurinol can reduce the effectiveness of azathioprine and mercaptopurine, increasing the risk of toxicity.
• When taken with ampicillin or amoxicillin, the risk of developing a rash may increase.
• May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
• Concomitant use with didanosine may increase the risk of developing peripheral neuropathy.
• The effectiveness of uricosuric drugs like probenecid or sulfinpyrazone can be reduced by Allopurinol.
• Cyclosporine levels may be increased, necessitating close monitoring of cyclosporine concentrations.
• When combined with chlorpropamide, the risk of bone marrow suppression and/or hypoglycemia may increase.

Following are the food interactions for Allopurinol 300mg Tablet:

• Allopurinol may cause a reduction in vitamin C levels in the body, so consider increasing your intake of vitamin C-rich foods like citrus fruits, strawberries, and broccoli.
• Alcohol should be avoided as it can increase the risk of liver problems and may also decrease the effectiveness of Allopurinol.
• Avoid high-purine foods such as organ meats, game meats, anchovies, herring, and gravies. These can increase uric acid levels and reduce the medication's effectiveness.
• Stay well-hydrated by drinking plenty of fluids, especially water, to help prevent kidney stones and promote the excretion of uric acid.
• Limit or avoid sugary foods and beverages, as high sugar intake can contribute to weight gain and increase the risk of gout attacks.
• Consume a balanced diet rich in complex carbohydrates, lean proteins, and healthy fats to support overall health and maintain a healthy weight.
• Consider including low-fat dairy products as they may have a protective effect against gout due to their potential to reduce uric acid levels.
• Avoid high-fat meals as they can affect the absorption and distribution of Allopurinol.

Allopurinol 300mg Tablets should be stored in a cool, dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in bathrooms or near heat sources like ovens or radiators, as temperature fluctuations can impact their effectiveness. Always check the expiration date, and if the tablets are past their prime or no longer needed, do not flush them or dispose of them through the sink. Consult your pharmacist or healthcare professional for the correct disposal method to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Allopurinol 300mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet with a full glass of water to aid in swallowing.
• Take the tablet after a meal to minimize gastrointestinal side effects.
• Maintain a consistent time for taking the medication for better effectiveness.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Regularly monitor your uric acid levels and kidney function while on this medication.