Telfast: This drug (fexofenadine) is a Histamine 1 antagonist (antihistamine) Second Generation; Piperidine Derivative antiallergic drug. The H1 histamine receptor is responsible for mediating hypersensitivity and allergic reactions. After an exposure to an allergen the degranulation of mast cells and basophils occurs, which then release histamine and other inflammatory mediators. Histamine binds to, and activates, H1 receptors, which further releases pro-inflammatory cytokines, such as interleukins, from basophils and mast cells. This mechanism of histamine binding is responsible for a wide variety of allergic symptoms, such as pruritus, rhinorrhea, and watery eyes. Fexofenadine binds to and stabilizes the inactive form of the receptor, and prevents its activation and subsequent downstream effects. Fexofenadine does not cross the blood-brain barrier and may not cause significant CNS effects.
Uses
Fexofenadine hydrochloride tablets are indicated for the relief of symptoms associated with seasonal Allergic Rhinitis in adults and children 2 years of age and older. Chronic Idiopathic Urticaria in adults and children 6 months of age and older.
Dose
Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Seasonal Allergic Rhinitis and Chronic Idiopathic Urticaria Adults and Children 12 Years and Older: The recommended dose of Fexofenadine hydrochloride tablets USP are 60 mg twice daily or 180 mg once daily with water. A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function. Children 6 to 11 Years: The recommended dose of Fexofenadine hydrochloride tablets USP are 30 mg twice daily with water. A dose of 30 mg once daily is recommended as the starting dose in pediatric patients with decreased renal function.
Over Dose
Dizziness, drowsiness, and dry mouth have been reported with Fexofenadine hydrochloride overdose. In the event of overdose, your doctor will consider standard measures to remove any unabsorbed drug. Symptomatic and supportive treatment is recommended.
Missed Dose
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.
How To Use
Take it orally according to the doctor's advice.
When Not Use
Fexofenadine hydrochloride tablets are contraindicated in patients with known hypersensitivity to Fexofenadine and any of the ingredients of Fexofenadine hydrochloride tablets. Rare cases of hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnea, flushing and systemic anaphylaxis have been reported.
Precautions
Use with caution in patients with renal impairment
