Ciprofloxacin is a second generation fluoroquinolone antibiotic. This drug is active against many gram positive and gram negative bacteria. This drug performs its actions by binding to DNA gyrase and topoisomerase IV. Ciprofloxacin acts on alpha subunits of DNA gyrase and prevents its supercoiling and introduces double-stranded breaks into DNA and prevents its replication.
Pneumonia, Chronic Obstructive Pulmonary Disease (COPD),Urinary Tract Infections (UTI), Plague, Typhoid Fever, Gonorrhea, Diarrheal infections, Bone and Joint Infections, Skin Infections, Chronic Prostate Infections, Sinusitis
Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: For acute sinusitis: 500mg orally after every 12 hours for 10 days. For mild to moderate bone & joint infections: 500mg orally after every 12 for ≥4-6 weeks For severe bone & joint infections: 750mg orally after every 12 hours for ≥4-6 weeks. For chronic bacterial prostatitis: 500mg orally after every 12 hours for 28 days. For infectious diarrhea: 500mg orally after every 12 hours for 5-7 days. For complicated intra-abdominal infections: 500mg orally after every 12 hours for 7-14 days. For mild to moderate lower respiratory tract infections: 500mg orally after every 12 hours. For severe to complicated lower respiratory tract infections: 750mg orally after every 12 for 7-14 days. For mild to moderate skin infections: 500mg orally after every 12 hours for 7-14 days. For severe to complicated skin infections: 750mg orally after every 12hr for 7-14 days. For acute and uncomplicated urinary tract infections: Immediate-release tablets/capsules, 250mg orally after every 12 hours for 3 days; extended-release tablets/capsules, 500mg orally after every 24 hours for 3 days. For mild to moderate urinary tract infections: 250mg orally after every 12 hours for 7-14 days. For severe or complicated urinary tract infections: 500mg orally after every 12 hours for 7-14 days. For urethral & cervical gonococcal infections: 250-500mg once orally. For anthrax infection: 500mg orally after every 12 hours for 60 days. For plague: 500-750mg orally after every 12 hours for 14 days. Child dose: For urinary tract infections including kidney infections: In children of age 1 to 17 years; 10mg/kg to 20mg/kg (maximum of 750mg per dose) orally every 12 hours for 10 to 21 days. For prevention of anthrax infection after exposure in children from birth to 17 years; 15mg/kg (max 500mg per dose) every 12 hours for 60 days. For Plague from birth to 17 years: 15mg/kg (maximum of 500mg per dose) every 8 to 12 hours for 14 days.
Overdose may cause nausea, vomiting, diarrhea and a pounding or irregular heartbeat. If a patient is epileptic then he may face seizures or fits. Kaolin or magnesium trisilicate could be used as an antidote for ciprofloxacin overdose; these antidotes would decrease the absorption of ciprofloxacin in case of oral ingestion.
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.
How To Use
Take this medicine orally with water. Crystalluria may occur as an adverse effect. Increased alkalinity of urine may contribute towards risks so the patient should keep himself hydrated along with use of this medicine.
When Not Use
Should not be given to the patients who are hypersensitive to clarithromycin or any fluoroquinolone antibiotic. It may enhance muscle weakness in patients with myasthenia gravis so should not be taken in this case.
This drug may enhance the risk for aortic aneurysm (bulge in the wall of the largest artery), so a patient should consult a doctor if he feels sudden chest, stomach, or back pain, trouble breathing, cough, or hoarseness.
Nause Diarrhea Lightheadedness Dizziness Headache Trouble sleeping Hypersensitivity reactions Arthralgia Asthenia Joint stiffness Tremor.
Store below 30°C. Protect from heat, sunlight.