Patient's Complete Guide to Progressive Supranuclear Palsy

Overview of Progressive Supranuclear Palsy

Progressive Supranuclear Palsy is a brain disorder that involves unwanted accumulation of a brain protein on brain cells resulting in difficulty in body coordination and movement as well as problems in speech and eye movement.

Signs and Symptoms of Progressive Supranuclear Palsy

Progressive Supranuclear Palsy (PSP) is a brain disorder that happens due to the deterioration of regions within the brain causing loss of eye and body movement, coordination, and balance. Supranuclear are basically the nuclei of the nerve cells that are damaged which results in an overall state of weakness, palsy.

About every 3-6 individuals in every 100,000 have PSP, making it much less common than Parkinson’s disease. The risk factor associated with PSP primarily has to do with one’s age mostly affecting people in the 60 plus age bracket. So far there is no cure to treat PSP except treatment options to alleviate the symptoms pertaining to it.

Types of Progressive Supranuclear Palsy

The symptoms associated with PSP vary from person to person, however, common signs are that people lose their balance often and have problems in mobility. They also have slow eye movement and have difficulty in shifting their gaze vertically. Other possible symptoms are a change in behavior where one loses interest in otherwise engaging activities, difficulty in problem-solving situations, and showcasing impulsive behavior, as well as being irritable most of the time. These symptoms can worsen as the disorder progresses affecting speech delivery and loss of memory.
Symptoms of Parkinson’s Disease and PSP overlap quite a lot because of which PSP is often misdiagnosed with the former. The doctor, therefore, has to rule out other possible conditions that might be a cause of the symptoms before correctly diagnosing PSP.

Causes of Progressive Supranuclear Palsy

There are five types of PPS based on differences in the severity of brain damage and the distribution of the damage.

  1. Richardson’s syndrome- Difficulty in vertical eye movement, postural instability, deterioration in cognitive abilities, and change in personality.
  2. PSP-Parkinsonism- Limb rigidity and cognitive dysfunction
  3. PSP-Pure akinesia with gait freezing- Freezing of gait and inability to move muscles voluntarily
  4. PSP-Corticobasal syndrome- Uncontrollable muscle contraction and eye movement abnormality
  5. Progressive non-fluent aphasia- Non Fluent in spontaneous speech

In case you exhibit any concerning signs and symptoms for PSP, consult a medical professional as soon as possible.

Risk Factors of Progressive Supranuclear Palsy

The deposition of an abnormal amount of protein, tau, on the brain cells results in brain damage. Tau is normally present in the brain and is broken down if it is in excess. However, in people with PSP, tau is not broken down properly as a result of which it brings about its effect by damaging brain cells as it forms clumps within the cells. Substantia nigra is one of the regions where tau accumulates. This is also the region affected in Parkinson’s Disease and explains why there is an overlap of symptoms between the two conditions.

Treatment of Progressive Supranuclear Palsy | When to Consult a Doctor

People suffering from PSP might become disabled 3-5 years from its onset. If PSP progresses through the years, symptoms might worsen leading to severe complications which include pneumonia, fracture, and head injury. Due to these complications, the lifespan of people with PSP is around 5 years after diagnosis. Progression of PSP can transition from an early stage, consisting of symptoms that can be treated, such as poor balance, mood changes, and slight visual problems, to a late stage, where the symptoms become beyond healable, severe visual problems, reduced consciousness, and acute infections.

Healthcare Providers

Consult with Best Doctors for Progressive Supranuclear Palsy

Prof. Dr. Shahzad Shams, Neurosurgeon
Thumbsup
97%
Assoc. Prof. Dr. Syed Shahzad Hussain, Neurosurgeon
Thumbsup
97%
Prof. Dr. Muhammad Athar Javed, Neurologist
Thumbsup
97%
Prof. Dr. Nazir Ahmad, Neurosurgeon
Thumbsup
97%
Dr. Saeed Ahmad Bajwa, Neurosurgeon
Thumbsup
97%
Dr. Anjum Habib Vohra, Neurosurgeon
Thumbsup
97%
Dr. Asim Mahmood, Neurosurgeon
Thumbsup
97%

Dr. Asim Mahmood

Dr. Amer Ikram, Neurologist
Thumbsup
97%

Dr. Amer Ikram

Dr. Aamir Aziz, Neurosurgeon
Thumbsup
97%

Dr. Aamir Aziz

Dr. Muhammad Khurrum Ishaque, Neurosurgeon
Thumbsup
97%

Speciality for Progressive Supranuclear Palsy

Call for assistance
042 32500989