Paget's Disease

Overview of Paget's Disease

A bone disorder in which the bone remodeling process is disrupted. Certain medications can help to reduce the effects of this disease. In some more complex scenarios, your doctor may perform surgery to help you overcome this disease.

Signs and Symptoms of Paget's Disease

In Paget’s disease, the normal recycling process of bones is disrupted. The old bone tissues degenerate really quickly and as a result, the new bone forms is pretty fragile and misshapen. One may become more vulnerable to this disease if it already exists in his/her family. It is more likely to happen at one age.
Certain medications can help to reduce the effects of this disease. In some more complex scenarios, your doctor may perform surgery to help you overcome this disease.

What is Paget’s disease?

It’s the most common bone disorder after arthritis.
Paget’s disease is basically a disorder of the bone remodeling process in which the body absorbs old bone and forms abnormal new bones. Due to the degenerative process of old bone tissues, the new abnormal bones may generate in incorrect locations. Some old bones that are not to be removed might also get degenerated.
The bones of a Paget disease patient become fragile and sensitive over time and require a long time to heal as the bone renewal process gets slowed and disrupted.

Find the suitable doctor treating this disease

View doctors

Types of Paget's Disease

Usually, the patients of Paget’s disease do not experience any symptoms. This disease is more likely to cause internal damage and rarely shows its presence without causing much harm. Due to this, the patients of this disease are often misdiagnosed as well.

Some common symptoms of Paget’s disease include:

  • Bone/joint pain
  • Swelling of joints
  • Tender joints
  • Redness of the skin around joints or bones
  • Delayed healing of bones
  • Weakness in bones
  • Easily fractured bones

Risk Factors of Paget's Disease

Till now, the cause of this disease is still to be found. This disease in some cases tends to run in families. An infection due to measles during childhood can cause this disease.



This bone disorder occurs most commonly in these bones:

  • Pelvis area

Paget’s disease in the pelvis area can cause hip pain.

  • Spine

This disease in the spine can cause numbness, tingling or pain in arms or legs. As the nerve roots in the spine can get compressed.

  • Skull

This disorder in the skull can cause an overgrowth of bone and cause hearing loss or severe headaches.

  • Thighbone (Femur) and Shinbone (Tibia)

As the bones become weaker and fragile, an individual can become bow-legged ( the legs are curved outwards while the feet and ankles touch). Due to overgrown and misshapen bones, one may feel extra stress on joints. This can cause osteoarthritis in the knee or hip.


Timely detection and proper treatment of this disease in most cases bear fruitful results. In some cases due to co-morbidities and more complex scenarios, Paget’s disease can cause more serious health problems like:

  • Hearing impairment
  • Heart issues
  • Nervous system issues
  • Arthritis
  • Teeth loosening

In very rare cases, a person may develop “Paget’s Sarcoma”. Only 1% of patients with Paget’s disease suffer from this cancer.


Treatment of Paget's Disease | When to Consult a Doctor

Usually, Paget’s disease is identified by conducting a blood test and an X-Ray or a nuclear imaging test.

Blood tests determine the level of Alkaline Phosphatase (APL) in the patient’s body. If someone is suffering from Paget’s disease, he/she would have elevated levels of APL. However, raised levels of ALP do not necessarily mean that the person has Paget’s disease. The levels may be raised due to some other medical condition. And in some cases, people who actually had Paget’s disease had normal ALP levels.
Therefore, an X-Ray is also required for the confirmation of the disease. X-rays clearly show the structure of the bone and your doctor will be able to see if the bones are enlarged or misshapen. In some cases, a test called scintigraphy is also conducted. This is a nuclear imaging test and gives more accurate, precise, and detailed results. This test shows those areas where a lot of bone renewal processes are taking place.

Depending on the patients’ conditions, the following tests can also be done:

  • Bone Biopsy
  • CT Scan
  • MRI-Scan

Doctors to treat Paget's Disease

Last updated on Wednesday 31/08/2022


Prof. Dr. M. Tariq Sohail

Orthopedic Surgeon | MBBS, Masters in Orthopedics , FRCS , FICS

Doctors HospitalRs 3000


Today’s Slots


Satisfaction Rate



Satisfied with Dr. treatment.


Dr. Shahzad Anver Qureshi

Orthopedic Surgeon | MBBS, FCPS

Masood HospitalRs 2500


Today’s Slots


Satisfaction Rate



Highly Recommended


Dr. Muhammad Khalid

Orthopedic Surgeon | MBBS, FCPS (ortho), Fellowship in Spine

Hameed Latif HospitalRs 2500


Today’s Slots


Satisfaction Rate



The doctor was very nice and helping.

All Doctors treating Paget's Disease